PrP-associated resistance to scrapie in five highly infected goat herds

The PrP gene polymorphisms at codons 142 (I/M), 154 (R/H), 211 (R/Q), 222 (Q/K) and 240 (S/P) and their association with susceptibility to classical scrapie infection were investigated in five French goat herds displaying a high disease prevalence (>10%). On the basis of PrP(Sc) detection in the...

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Bibliographic Details
Published in:Journal of general virology 2013-01, Vol.94 (Pt 1), p.241-245
Main Authors: Corbière, Fabien, Perrin-Chauvineau, Cécile, Lacroux, Caroline, Costes, Pierrette, Thomas, Myriam, Brémaud, Isabelle, Martin, Samuel, Lugan, Séverine, Chartier, Christophe, Schelcher, François, Barillet, Francis, Andreoletti, Olivier
Format: Article
Language:English
Subjects:
Alleles
Animals
Central Nervous System - immunology
Central Nervous System - metabolism
France - epidemiology
Genetic Predisposition to Disease
Goat Diseases - epidemiology
Goat Diseases - genetics
Goat Diseases - immunology
Goats
Life Sciences
Lymphoid Tissue - immunology
Lymphoid Tissue - metabolism
Mutation
Polymorphism, Genetic
Prevalence
Prions - genetics
Scrapie - epidemiology
Scrapie - genetics
Scrapie - immunology
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Summary:The PrP gene polymorphisms at codons 142 (I/M), 154 (R/H), 211 (R/Q), 222 (Q/K) and 240 (S/P) and their association with susceptibility to classical scrapie infection were investigated in five French goat herds displaying a high disease prevalence (>10%). On the basis of PrP(Sc) detection in the central nervous system and in various lymphoid tissues, 301 of 1343 goats were found to be scrapie infected. The statistical analyses indicated that while P(240) mutation had no direct impact on scrapie infection risk, the H(154), Q(211) and K(222) mutations were associated with high resistance to scrapie. The M(142) mutated allele was associated with a limited protection level against the disease. These results further reinforce the view that, like in sheep, the control and eradication of classical scrapie through the selection of certain PrP alleles could be envisaged in commercial goat population.
ISSN:0022-1317
1465-2099
1465-2099
DOI:10.1099/vir.0.047225-0