A dairy fat matrix providing alpha-linolenic acid (ALA) is better than a vegetable fat mixture to increase brain DHA accretion in young rats

Abstract Achieving an appropriate DHA status in the neonatal brain is an important goal of neonatal nutrition. We evaluated how alpha-linolenic acid (ALA), provided for six weeks after weaning by different dietary fat matrix, improved brain DHA content of young male rats born from deficient-dams. Th...

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Bibliographic Details
Published in:Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 2013-01, Vol.88 (1), p.115-120
Main Authors: Delplanque, B, Du, Q, Agnani, G, Le Ruyet, P, Martin, J.C
Format: Article
Language:English
Subjects:
Advanced Basic Science
Alpha-linolenic acid (ALA)
alpha-Linolenic Acid - administration & dosage
alpha-Linolenic Acid - deficiency
alpha-Linolenic Acid - metabolism
alpha-Linolenic Acid - therapeutic use
Animals
Brain
Brain - metabolism
Dairy fat
Dairy Products
Dietary Fats - metabolism
Docosahexaenoic acid (DHA)
Docosahexaenoic Acids - metabolism
Endocrinology & Metabolism
Food, Fortified - analysis
Glycolipids - metabolism
Glycoproteins - metabolism
Humans
Infant
Infant Formula - chemistry
Infant Formula - metabolism
LA/ALA ratio
Life Sciences
Male
Neurogenesis
Neurons - metabolism
Nutritional Status
Palm oil
Plant Oils - metabolism
Rapeseed oil
Rat neonates
Rats
Rats, Wistar
Up-Regulation
Weaning
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Summary:Abstract Achieving an appropriate DHA status in the neonatal brain is an important goal of neonatal nutrition. We evaluated how alpha-linolenic acid (ALA), provided for six weeks after weaning by different dietary fat matrix, improved brain DHA content of young male rats born from deficient-dams. The level of ALA achieved was based on the fat composition of usual infant vegetable formula. A palm oil-blend diet thus providing 1.5%ALA was compared to dairy fat-blend-based diets that provided either 1.5%ALA or 2.3%ALA, or a rapeseed oil diet providing 8.3%ALA ( n −6/ n −3 ratio were, respectively 10,10,5,2.5). The 1.5%ALA-dairy-fat-blend was superior to 1.5%ALA-palm-oil-blend to restore values of brain DHA, while the 2.3%ALA-dairy-fat-blend exhibited a further increase and reached the values obtained with pure rapeseed diet (8.3%ALA). Dairy-fat-blends enriched with ALA appear to be an interesting strategy for achieving optimal DHA levels in the brain of post-weaning rats. Providing dairy fat as well as a reduction of the LA/ALA ratio should be reconsidered to design infant formula.
ISSN:0952-3278
1532-2823
DOI:10.1016/j.plefa.2012.07.004