PRIMARY MENINGEAL T-CELL LYMPHOMA IN A HARBOR SEAL (PHOCA VITULINA)

A 15-year-old female harbor seal (Phoca vitulina) was referred to the Nantes Veterinary School, Nantes, France, with a clinical history of anorexia, seizures, and left hemiplegia. Cerebrospinal fluid analysis revealed large numbers of neoplastic lymphoid cells. After injection of a contrast agent in...

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Bibliographic Details
Published in:Journal of zoo and wildlife medicine 2007-06, Vol.38 (2), p.323-328
Main Authors: Labrut, Sophie, Wyers, Monique, Miclard, Julien, Colle, Marie-Anne
Format: Article
Language:English
Subjects:
Animals
Brain
Case Report
Case Reports
Diagnosis, Differential
Fatal Outcome
Female
harbor seal
Histology
Immunohistochemistry - veterinary
Lesions
Life Sciences
Lymphocytes
Lymphoma
Lymphoma, T-Cell - diagnosis
Lymphoma, T-Cell - pathology
Lymphoma, T-Cell - veterinary
Marine
meningeal
Meningeal Neoplasms - diagnosis
Meningeal Neoplasms - pathology
Meningeal Neoplasms - veterinary
Meninges
Pathology
Phoca
Phoca vitulina
pinniped
Seals
Squamous cell carcinoma
tumor
Tumors
Zoos
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Summary:A 15-year-old female harbor seal (Phoca vitulina) was referred to the Nantes Veterinary School, Nantes, France, with a clinical history of anorexia, seizures, and left hemiplegia. Cerebrospinal fluid analysis revealed large numbers of neoplastic lymphoid cells. After injection of a contrast agent into the cerebrospinal space, radiographs demonstrated an asymmetry of the right lateral ventricle. Necropsy examination revealed a marked edema of the right frontal lobe, extending to the basal nuclei and thalamus in the brain. Histological examination of the brain revealed leptomeningeal lymphoma. Immunohistochemical labeling demonstrated that the neoplasm was of T-cell origin. No significant macroscopic or microscopic lesions were observed in the other organs examined, including lymphoid organs. This is the first report of primary leptomeningeal lymphoma in a harbor seal.
ISSN:1042-7260
1937-2825
DOI:10.1638/1042-7260(2007)038[0323:PMTLIA]2.0.CO;2