Identification of atypical scrapie in Canadian sheep

Scrapie, a transmissible spongiform encephalopathy of sheep and goats, exists in most small ruminant-producing countries of the world. A novel form of this disease was recently recognized and is known by various names, including Nor98, Nor98-like, and atypical scrapie. Differing from classic scrapie...

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Bibliographic Details
Published in:Journal of veterinary diagnostic investigation 2010-05, Vol.22 (3), p.408-411
Main Authors: Mitchell, Gordon B, O'Rourke, Katherine I, Harrington, Noel P, Soutyrine, Andrei, Simmons, Marion M, Dudas, Sandor, Zhuang, Dongyue, Laude, Hubert, Balachandran, Aru
Format: Article
Language:English
Subjects:
Animals
atypical scrapie
Blotting, Western
Canada - epidemiology
Codon - genetics
diagnostic techniques
disease detection
disease prevalence
disease surveillance
emerging diseases
epidemiological studies
geographical distribution
Goat Diseases - epidemiology
Goat Diseases - virology
Goats
Immunoblotting - methods
Life Sciences
Nor98 scrapie
Nor98-like scrapie
pathotypes
Prion Diseases - diagnosis
Prion Diseases - epidemiology
Prion Diseases - veterinary
Prion Diseases - virology
Prions - genetics
Prions - pathogenicity
PrPSc Proteins - classification
PrPSc Proteins - genetics
PrPSc Proteins - pathogenicity
risk assessment
scrapie
Scrapie - epidemiology
Sheep
Sheep Diseases - epidemiology
Sheep Diseases - virology
strains
United States
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Summary:Scrapie, a transmissible spongiform encephalopathy of sheep and goats, exists in most small ruminant-producing countries of the world. A novel form of this disease was recently recognized and is known by various names, including Nor98, Nor98-like, and atypical scrapie. Differing from classic scrapie in epidemiology, histopathology, and biochemical characteristics, atypical scrapie cases have been identified throughout Europe and in the United States. Enhanced scrapie surveillance efforts recently identified 3 cases of atypical scrapie in Canada.
ISSN:1040-6387
1943-4936
DOI:10.1177/104063871002200310