Polysaccharide Storage Myopathy in Cob Normand Draft Horses

Gluteus medius muscle was sampled from 53 Cob Normand horses for histologic evaluation. Twenty horses (38%) exhibited amylase-resistant material in myocytes consistent with polysaccharide storage myopathy. Diameter of affected type II fibers was increased (67.7 ± 21.4 μm) compared with normal ones (...

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Bibliographic Details
Published in:Veterinary pathology 2008-03, Vol.45 (2), p.154-158
Main Authors: Larcher, T, Herszberg, B, Molon-Noblot, S, Guigand, L, Chaffaux, S, Guerin, G, Cherel, Y
Format: Article
Language:English
Subjects:
Animals
biopsy
Biopsy - veterinary
carbohydrate metabolism disorders
draft animals
equine polysaccharide storage myopathy
Glycogen Storage Disease - metabolism
Glycogen Storage Disease - pathology
Glycogen Storage Disease - veterinary
Histocytochemistry - veterinary
histopathology
horse breeds
Horse Diseases - metabolism
Horse Diseases - pathology
Horses
Life Sciences
Microscopy, Electron, Transmission - veterinary
muscle fibers
Muscle, Skeletal - metabolism
Muscle, Skeletal - ultrastructure
muscular diseases
Muscular Diseases - metabolism
Muscular Diseases - pathology
Muscular Diseases - veterinary
myocytes
polysaccharides
Polysaccharides - metabolism
skeletal muscle
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Summary:Gluteus medius muscle was sampled from 53 Cob Normand horses for histologic evaluation. Twenty horses (38%) exhibited amylase-resistant material in myocytes consistent with polysaccharide storage myopathy. Diameter of affected type II fibers was increased (67.7 ± 21.4 μm) compared with normal ones (57.3 ± 19.7 μm). Two groups were distinguished by quantitative study. The first group (n = 14; 26%) was characterized by a low percentage of fibers (m = 0.98%) containing aggregates occurring singly or in perifascicular clusters without myopathic changes. The second group (n = 6; 11%) was characterized by a high percentage (m = 18.1%) of fibers containing aggregates scattered in biopsy with chronic myopathic changes. Rebiopsy of 4 horses showed an increase with time in the number of aggregate-containing fibers for horses of the first group only. In 1 necropsied horse, aggregates were observed in a wide range of muscles including smooth muscles. Ultrastructurally, granular material was found interspersed among arrays of filamentous material.
ISSN:0300-9858
1544-2217
DOI:10.1354/vp.45-2-154