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Polysaccharide Storage Myopathy in Cob Normand Draft Horses
Gluteus medius muscle was sampled from 53 Cob Normand horses for histologic evaluation. Twenty horses (38%) exhibited amylase-resistant material in myocytes consistent with polysaccharide storage myopathy. Diameter of affected type II fibers was increased (67.7 ± 21.4 μm) compared with normal ones (...
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| Published in: | Veterinary pathology 2008-03, Vol.45 (2), p.154-158 |
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| cites | cdi_FETCH-LOGICAL-c378t-e724e1d71f6e8a42f6e829fc6ad3a7be87b2ac92ffed46c9af16ac7d36a10e923 |
| container_end_page | 158 |
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| container_title | Veterinary pathology |
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| creator | Larcher, T Herszberg, B Molon-Noblot, S Guigand, L Chaffaux, S Guerin, G Cherel, Y |
| description | Gluteus medius muscle was sampled from 53 Cob Normand horses for histologic evaluation. Twenty horses (38%) exhibited amylase-resistant material in myocytes consistent with polysaccharide storage myopathy. Diameter of affected type II fibers was increased (67.7 ± 21.4 μm) compared with normal ones (57.3 ± 19.7 μm). Two groups were distinguished by quantitative study. The first group (n = 14; 26%) was characterized by a low percentage of fibers (m = 0.98%) containing aggregates occurring singly or in perifascicular clusters without myopathic changes. The second group (n = 6; 11%) was characterized by a high percentage (m = 18.1%) of fibers containing aggregates scattered in biopsy with chronic myopathic changes. Rebiopsy of 4 horses showed an increase with time in the number of aggregate-containing fibers for horses of the first group only. In 1 necropsied horse, aggregates were observed in a wide range of muscles including smooth muscles. Ultrastructurally, granular material was found interspersed among arrays of filamentous material. |
| doi_str_mv | 10.1354/vp.45-2-154 |
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Twenty horses (38%) exhibited amylase-resistant material in myocytes consistent with polysaccharide storage myopathy. Diameter of affected type II fibers was increased (67.7 ± 21.4 μm) compared with normal ones (57.3 ± 19.7 μm). Two groups were distinguished by quantitative study. The first group (n = 14; 26%) was characterized by a low percentage of fibers (m = 0.98%) containing aggregates occurring singly or in perifascicular clusters without myopathic changes. The second group (n = 6; 11%) was characterized by a high percentage (m = 18.1%) of fibers containing aggregates scattered in biopsy with chronic myopathic changes. Rebiopsy of 4 horses showed an increase with time in the number of aggregate-containing fibers for horses of the first group only. In 1 necropsied horse, aggregates were observed in a wide range of muscles including smooth muscles. Ultrastructurally, granular material was found interspersed among arrays of filamentous material.</description><identifier>ISSN: 0300-9858</identifier><identifier>EISSN: 1544-2217</identifier><identifier>DOI: 10.1354/vp.45-2-154</identifier><identifier>PMID: 18424827</identifier><language>eng</language><publisher>Los Angeles, CA: American College of Veterinary Pathologists</publisher><subject>Animals ; biopsy ; Biopsy - veterinary ; carbohydrate metabolism disorders ; draft animals ; equine polysaccharide storage myopathy ; Glycogen Storage Disease - metabolism ; Glycogen Storage Disease - pathology ; Glycogen Storage Disease - veterinary ; Histocytochemistry - veterinary ; histopathology ; horse breeds ; Horse Diseases - metabolism ; Horse Diseases - pathology ; Horses ; Life Sciences ; Microscopy, Electron, Transmission - veterinary ; muscle fibers ; Muscle, Skeletal - metabolism ; Muscle, Skeletal - ultrastructure ; muscular diseases ; Muscular Diseases - metabolism ; Muscular Diseases - pathology ; Muscular Diseases - veterinary ; myocytes ; polysaccharides ; Polysaccharides - metabolism ; skeletal muscle</subject><ispartof>Veterinary pathology, 2008-03, Vol.45 (2), p.154-158</ispartof><rights>2008 American College of Veterinary Pathologists</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c378t-e724e1d71f6e8a42f6e829fc6ad3a7be87b2ac92ffed46c9af16ac7d36a10e923</citedby><cites>FETCH-LOGICAL-c378t-e724e1d71f6e8a42f6e829fc6ad3a7be87b2ac92ffed46c9af16ac7d36a10e923</cites><orcidid>0000-0002-0396-3190</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27923,27924,79135</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18424827$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.inrae.fr/hal-02658616$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Larcher, T</creatorcontrib><creatorcontrib>Herszberg, B</creatorcontrib><creatorcontrib>Molon-Noblot, S</creatorcontrib><creatorcontrib>Guigand, L</creatorcontrib><creatorcontrib>Chaffaux, S</creatorcontrib><creatorcontrib>Guerin, G</creatorcontrib><creatorcontrib>Cherel, Y</creatorcontrib><title>Polysaccharide Storage Myopathy in Cob Normand Draft Horses</title><title>Veterinary pathology</title><addtitle>Vet Pathol</addtitle><description>Gluteus medius muscle was sampled from 53 Cob Normand horses for histologic evaluation. Twenty horses (38%) exhibited amylase-resistant material in myocytes consistent with polysaccharide storage myopathy. Diameter of affected type II fibers was increased (67.7 ± 21.4 μm) compared with normal ones (57.3 ± 19.7 μm). Two groups were distinguished by quantitative study. The first group (n = 14; 26%) was characterized by a low percentage of fibers (m = 0.98%) containing aggregates occurring singly or in perifascicular clusters without myopathic changes. The second group (n = 6; 11%) was characterized by a high percentage (m = 18.1%) of fibers containing aggregates scattered in biopsy with chronic myopathic changes. Rebiopsy of 4 horses showed an increase with time in the number of aggregate-containing fibers for horses of the first group only. In 1 necropsied horse, aggregates were observed in a wide range of muscles including smooth muscles. Ultrastructurally, granular material was found interspersed among arrays of filamentous material.</description><subject>Animals</subject><subject>biopsy</subject><subject>Biopsy - veterinary</subject><subject>carbohydrate metabolism disorders</subject><subject>draft animals</subject><subject>equine polysaccharide storage myopathy</subject><subject>Glycogen Storage Disease - metabolism</subject><subject>Glycogen Storage Disease - pathology</subject><subject>Glycogen Storage Disease - veterinary</subject><subject>Histocytochemistry - veterinary</subject><subject>histopathology</subject><subject>horse breeds</subject><subject>Horse Diseases - metabolism</subject><subject>Horse Diseases - pathology</subject><subject>Horses</subject><subject>Life Sciences</subject><subject>Microscopy, Electron, Transmission - veterinary</subject><subject>muscle fibers</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Muscle, Skeletal - ultrastructure</subject><subject>muscular diseases</subject><subject>Muscular Diseases - metabolism</subject><subject>Muscular Diseases - pathology</subject><subject>Muscular Diseases - veterinary</subject><subject>myocytes</subject><subject>polysaccharides</subject><subject>Polysaccharides - metabolism</subject><subject>skeletal muscle</subject><issn>0300-9858</issn><issn>1544-2217</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNp1kU1rGzEQQEVoid20p9zTPYWGsqk0q5W05GScDwfcD0h9FmOtFG9YWxtpbfC_r8ya5pTLDAyPd3hDyDmj16wo-Y9dd83LHHJW8hMyTpPnAEx-IGNaUJpXqlQj8inGF0oBKiVPyYgpDlyBHJObP77dRzRmhaGpbfbU-4DPNvu59x32q33WbLKpX2a_fFjjps5uA7o-m_kQbfxMPjpso_1y3GdkcX_3dzrL578fHqeTeW4KqfrcSuCW1ZI5YRVyOCyonBFYFyiXVskloKnAOVtzYSp0TKCRdSGQUVtBcUauBu8KW92FZo1hrz02ejaZ68ONgiiVYGLHEns5sF3wr1sbe71uorFtixvrt1GLioFipUrg9wE0wccYrPtvZlQfuupdp3mpQaeiib44arfLta3f2GPIBHwbgJjq6Re_DZuU5B3X1wF16DU-hybqxRNQlp6lVMWUKP4BUKCIjA</recordid><startdate>20080301</startdate><enddate>20080301</enddate><creator>Larcher, T</creator><creator>Herszberg, B</creator><creator>Molon-Noblot, S</creator><creator>Guigand, L</creator><creator>Chaffaux, S</creator><creator>Guerin, G</creator><creator>Cherel, Y</creator><general>American College of Veterinary Pathologists</general><general>SAGE Publications</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-0396-3190</orcidid></search><sort><creationdate>20080301</creationdate><title>Polysaccharide Storage Myopathy in Cob Normand Draft Horses</title><author>Larcher, T ; Herszberg, B ; Molon-Noblot, S ; Guigand, L ; Chaffaux, S ; Guerin, G ; Cherel, Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-e724e1d71f6e8a42f6e829fc6ad3a7be87b2ac92ffed46c9af16ac7d36a10e923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>biopsy</topic><topic>Biopsy - veterinary</topic><topic>carbohydrate metabolism disorders</topic><topic>draft animals</topic><topic>equine polysaccharide storage myopathy</topic><topic>Glycogen Storage Disease - metabolism</topic><topic>Glycogen Storage Disease - pathology</topic><topic>Glycogen Storage Disease - veterinary</topic><topic>Histocytochemistry - veterinary</topic><topic>histopathology</topic><topic>horse breeds</topic><topic>Horse Diseases - metabolism</topic><topic>Horse Diseases - pathology</topic><topic>Horses</topic><topic>Life Sciences</topic><topic>Microscopy, Electron, Transmission - veterinary</topic><topic>muscle fibers</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Muscle, Skeletal - ultrastructure</topic><topic>muscular diseases</topic><topic>Muscular Diseases - metabolism</topic><topic>Muscular Diseases - pathology</topic><topic>Muscular Diseases - veterinary</topic><topic>myocytes</topic><topic>polysaccharides</topic><topic>Polysaccharides - metabolism</topic><topic>skeletal muscle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Larcher, T</creatorcontrib><creatorcontrib>Herszberg, B</creatorcontrib><creatorcontrib>Molon-Noblot, S</creatorcontrib><creatorcontrib>Guigand, L</creatorcontrib><creatorcontrib>Chaffaux, S</creatorcontrib><creatorcontrib>Guerin, G</creatorcontrib><creatorcontrib>Cherel, Y</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Veterinary pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Larcher, T</au><au>Herszberg, B</au><au>Molon-Noblot, S</au><au>Guigand, L</au><au>Chaffaux, S</au><au>Guerin, G</au><au>Cherel, Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polysaccharide Storage Myopathy in Cob Normand Draft Horses</atitle><jtitle>Veterinary pathology</jtitle><addtitle>Vet Pathol</addtitle><date>2008-03-01</date><risdate>2008</risdate><volume>45</volume><issue>2</issue><spage>154</spage><epage>158</epage><pages>154-158</pages><issn>0300-9858</issn><eissn>1544-2217</eissn><abstract>Gluteus medius muscle was sampled from 53 Cob Normand horses for histologic evaluation. Twenty horses (38%) exhibited amylase-resistant material in myocytes consistent with polysaccharide storage myopathy. Diameter of affected type II fibers was increased (67.7 ± 21.4 μm) compared with normal ones (57.3 ± 19.7 μm). Two groups were distinguished by quantitative study. The first group (n = 14; 26%) was characterized by a low percentage of fibers (m = 0.98%) containing aggregates occurring singly or in perifascicular clusters without myopathic changes. The second group (n = 6; 11%) was characterized by a high percentage (m = 18.1%) of fibers containing aggregates scattered in biopsy with chronic myopathic changes. Rebiopsy of 4 horses showed an increase with time in the number of aggregate-containing fibers for horses of the first group only. In 1 necropsied horse, aggregates were observed in a wide range of muscles including smooth muscles. Ultrastructurally, granular material was found interspersed among arrays of filamentous material.</abstract><cop>Los Angeles, CA</cop><pub>American College of Veterinary Pathologists</pub><pmid>18424827</pmid><doi>10.1354/vp.45-2-154</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-0396-3190</orcidid></addata></record> |
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| ispartof | Veterinary pathology, 2008-03, Vol.45 (2), p.154-158 |
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| language | eng |
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| source | SAGE |
| subjects | Animals biopsy Biopsy - veterinary carbohydrate metabolism disorders draft animals equine polysaccharide storage myopathy Glycogen Storage Disease - metabolism Glycogen Storage Disease - pathology Glycogen Storage Disease - veterinary Histocytochemistry - veterinary histopathology horse breeds Horse Diseases - metabolism Horse Diseases - pathology Horses Life Sciences Microscopy, Electron, Transmission - veterinary muscle fibers Muscle, Skeletal - metabolism Muscle, Skeletal - ultrastructure muscular diseases Muscular Diseases - metabolism Muscular Diseases - pathology Muscular Diseases - veterinary myocytes polysaccharides Polysaccharides - metabolism skeletal muscle |
| title | Polysaccharide Storage Myopathy in Cob Normand Draft Horses |
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