Microcystic Meningioma in a Dolphin ( Delphinus delphis): Immunohistochemical and Ultrastructural Study

A wild common dolphin was found stranded on the French Atlantic coast. At necropsy, an intracranial grey- to tan-coloured mass (7 × 5 × 4 cm) was found at the right cerebellopontine angle, compressing the right cerebellar hemisphere, the brainstem and the occipital lobe of the right cerebral hemisph...

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Bibliographic Details
Published in:Journal of comparative pathology 2006-11, Vol.135 (4), p.254-258
Main Authors: Miclard, J., Mokhtari, K., Jouvion, G., Wyrzykowski, B., Van Canneyt, O., Wyers, M., Colle, M.A.
Format: Article
Language:English
Subjects:
Animals
brain
cetacean
dolphin
Dolphins
Female
Immunohistochemistry
Life Sciences
Meningeal Neoplasms - pathology
Meningeal Neoplasms - ultrastructure
Meningeal Neoplasms - veterinary
meningioma
Meningioma - pathology
Meningioma - ultrastructure
Meningioma - veterinary
Phosphopyruvate Hydratase - analysis
tumour
Vimentin - analysis
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Summary:A wild common dolphin was found stranded on the French Atlantic coast. At necropsy, an intracranial grey- to tan-coloured mass (7 × 5 × 4 cm) was found at the right cerebellopontine angle, compressing the right cerebellar hemisphere, the brainstem and the occipital lobe of the right cerebral hemisphere. Microscopically, the tumour was composed of small lobules of polygonal to elongated neoplastic cells with multifocal areas of stellate and vacuolated cells. Neoplastic cells strongly expressed vimentin, S-100 protein and neuron-specific enolase. They were rarely positive for cytokeratin. Ultrastructurally, the neoplastic cells displayed all the diagnostic features of meningiomas and in some areas showed long cytoplasmic processes delimiting extracellular spaces. The immunohistochemical and ultrastructural features were consistent with the histopathological diagnosis of a microcystic meningioma. This is the first report of a meningioma in dolphins or in any other cetacean species.
ISSN:0021-9975
1532-3129
DOI:10.1016/j.jcpa.2006.08.005