Hemorrhagic Hereditary Telangiectasia (Rendu-Osler Disease) and Infectious Diseases: An Underestimated Association

Among 353 patients with hereditary hemorrhagic telangiectasia retrospectively analyzed during the period 1985-2005, we identified 67 cases of severe infection that affected 48 patients (13.6%). Extracerebral infections accounted for 67% of all infections, and most involved Staphylococcus aureus and...

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Bibliographic Details
Published in:Clinical infectious diseases 2007-03, Vol.44 (6), p.841-845
Main Authors: Girod, Sophie Dupuis, Giraud, Sophie, Decullier, Evelyne, Lesca, Gaetan, Cottin, Vincent, Faure, Frédéric, Merrot, Olivier, Saurin, Jean-Christophe, Cordier, Jean-François, Plauchu, Henri
Format: Article
Language:English
Subjects:
Abscesses
Adolescent
Adult
Age Distribution
Aged
Aged, 80 and over
Arteriovenous malformations
Biological and medical sciences
Brain abscess
Brief Reports
Cardiology. Vascular system
Child
Cohort Studies
Communicable Diseases - epidemiology
Communicable Diseases - microbiology
Comorbidity
Congenital heart diseases. Malformations of the aorta, pulmonary vessels and vena cava
Correlation analysis
Dermatology
Endothelial cells
Epistaxis
Female
France - epidemiology
Genetic disorders
Genetic mutation
Heart
Hemorrhage
Hereditary hemorrhagic telangiectasia
Humans
Incidence
Infections
Infectious diseases
Life Sciences
Male
Medical sciences
Middle Aged
Non tumoral diseases
Otorhinolaryngology. Stomatology
Prognosis
Retrospective Studies
Risk Assessment
Severity of Illness Index
Sex Distribution
Staphylococcus infections
Survival Analysis
Telangiectasia, Hereditary Hemorrhagic - diagnosis
Telangiectasia, Hereditary Hemorrhagic - epidemiology
Telangiectasis
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
Vascular disorders of the skin
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Summary:Among 353 patients with hereditary hemorrhagic telangiectasia retrospectively analyzed during the period 1985-2005, we identified 67 cases of severe infection that affected 48 patients (13.6%). Extracerebral infections accounted for 67% of all infections, and most involved Staphylococcus aureus and were associated with prolonged epistaxis. Cerebral infections accounted for 33% of all infections, were mainly due to multiple and anaerobic bacteria, and were associated with the presence of pulmonary arteriovenous malformations and a short duration of epistaxis.
ISSN:1058-4838
1537-6591
DOI:10.1086/511645