Improvement of refractory rheumatoid arthritis-associated constrictive bronchiolitis with etanercept

Rheumatoid arthritis (RA)-associated constrictive bronchiolitis is a severe condition with no established efficient treatment. A 55-year-old woman with seropositive RA developed rapidly progressive constrictive bronchiolitis confirmed by lung biopsy. Her clinical condition worsened despite steroids...

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Bibliographic Details
Published in:Respiratory medicine 2005-04, Vol.99 (4), p.511-514
Main Authors: Cortot, Alexis Benjamin, Cottin, Vincent, Miossec, Pierre, Fauchon, Eric, Thivolet-Béjui, Françoise, Cordier, Jean-François
Format: Article
Language:English
Subjects:
Antirheumatic Agents - therapeutic use
Arthritis, Rheumatoid - complications
Arthritis, Rheumatoid - drug therapy
Arthritis, Rheumatoid - physiopathology
Biological and medical sciences
Bronchiolitis - drug therapy
Bronchiolitis - etiology
Bronchiolitis - physiopathology
Chronic obstructive pulmonary disease, asthma
Constrictive bronchiolitis
Disease
Diseases of the osteoarticular system
Drug therapy
Drug Therapy, Combination
Dyspnea - drug therapy
Dyspnea - etiology
Dyspnea - physiopathology
Etanercept
Female
Forced Expiratory Volume - drug effects
Humans
Immunoglobulin G - therapeutic use
Inflammatory joint diseases
Life Sciences
Lungs
Medical sciences
Methotrexate - therapeutic use
Middle Aged
Oxygen therapy
Pathogenesis
Pneumology
Receptors, Tumor Necrosis Factor - therapeutic use
Rheumatoid arthritis
Sarcoidosis
Treatment Outcome
Tumor necrosis factor- α
Vital Capacity - drug effects
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Summary:Rheumatoid arthritis (RA)-associated constrictive bronchiolitis is a severe condition with no established efficient treatment. A 55-year-old woman with seropositive RA developed rapidly progressive constrictive bronchiolitis confirmed by lung biopsy. Her clinical condition worsened despite steroids and azathioprine. Treatment with etanercept—a tumor necrosis factor (TNF)- α inhibitor—combined with methotrexate, resulted in a marked improvement of both her clinical condition and pulmonary function tests. Treatment with TNF- α inhibitors and methotrexate may be proposed in RA-associated constrictive bronchiolitis, a severe condition hitherto not amenable to improvement.
ISSN:0954-6111
1532-3064
DOI:10.1016/j.rmed.2004.09.001