Characterization of high-level fluoroquinolone resistance in Escherichia coli O78:K80 isolated from turkeys

Fluoroquinolone resistance was characterized in Escherichia coli O78:K80 isolated from diseased turkeys. The level of resistance to fluoroquinolones of the isolates appeared closely correlated with substitutions in GyrA and ParC, but not with the production of the AcrAB efflux pump. Among isolates h...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 2001-03, Vol.47 (3), p.341-343
Main Authors: Giraud, Etienne, Leroy-Sétrin, Sabine, Flaujac, Géraldine, Cloeckaert, Axel, Dho-Moulin, Maryvonne, Chaslus-Dancla, Elisabeth
Format: Article
Language:English
Subjects:
Amino Acid Substitution
Animals
Anti-Infective Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
Biological and medical sciences
Blotting, Western
Carrier Proteins
Ciprofloxacin - pharmacology
DNA Gyrase
DNA Topoisomerase IV
DNA Topoisomerases, Type II - genetics
DNA, Bacterial - genetics
DNA-Binding Proteins - genetics
Drug Resistance, Microbial
Enrofloxacin
Escherichia coli - drug effects
Escherichia coli - genetics
Escherichia coli - isolation & purification
Escherichia coli Proteins
Fluoroquinolones
Life Sciences
Lipoproteins - metabolism
Medical sciences
Membrane Proteins - metabolism
Membrane Transport Proteins
Microbial Sensitivity Tests
Multidrug Resistance-Associated Proteins
Mutation
Nalidixic Acid - pharmacology
Pharmacology. Drug treatments
Quinolizines - pharmacology
Quinolones - pharmacology
RNA, Ribosomal, 16S - genetics
RNA, Ribosomal, 23S - genetics
Turkeys - microbiology
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Summary:Fluoroquinolone resistance was characterized in Escherichia coli O78:K80 isolated from diseased turkeys. The level of resistance to fluoroquinolones of the isolates appeared closely correlated with substitutions in GyrA and ParC, but not with the production of the AcrAB efflux pump. Among isolates highly resistant to ciprofloxacin (MIC 8 mg/L) and harbouring identical substitutions (two in GyrA and one in ParC), two close but distinguishable ribotypes were identified. This indicated that at least two independent selection events may have occurred.
ISSN:0305-7453
1460-2091
1460-2091
DOI:10.1093/jac/47.3.341