Genetic Differences in Hypothalamic-Pituitary-Adrenal Axis Activity and Food Restriction-induced Hyperactivity in Three Inbred Strains of Rats

We used three inbred rat strains known for significant differences in the activity and reactivity of their hypothalamic‐pituitary‐adrenal (HPA) axis to stress [Fischer 344 (F344), Brown Norway (BN) and Lewis (Lew) rats] to search for a strain difference in the paradoxical increase in running activit...

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Bibliographic Details
Published in:Journal of neuroendocrinology 2005-11, Vol.17 (11), p.740-752
Main Authors: Duclos, M., Bouchet, M., Vettier, A., Richard, D.
Format: Article
Language:English
Subjects:
Adrenal Glands - physiology
Agouti-Related Protein
Animals
Attention deficit disorders. Hyperactivity
Biological and medical sciences
Body Composition - physiology
Body Weight - physiology
Brain Chemistry - physiology
Caloric Restriction
Child clinical studies
Corticosterone - blood
Eating - physiology
fat mass
Female
food restriction-induced hyperactivity
Fundamental and applied biological sciences. Psychology
genetic
HPA axis
Hyperkinesis - physiopathology
Hypothalamo-Hypophyseal System - physiology
Life Sciences
Medical sciences
Motor Activity - physiology
Nerve Tissue Proteins - metabolism
Neurons and Cognition
Organ Size - physiology
Peptide Fragments - metabolism
Pituitary-Adrenal System - physiology
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Rats
Rats, Inbred BN
Rats, Inbred F344
Rats, Inbred Lew
RNA, Messenger - biosynthesis
Species Specificity
Thymus Gland - physiology
Vertebrates: endocrinology
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Summary:We used three inbred rat strains known for significant differences in the activity and reactivity of their hypothalamic‐pituitary‐adrenal (HPA) axis to stress [Fischer 344 (F344), Brown Norway (BN) and Lewis (Lew) rats] to search for a strain difference in the paradoxical increase in running activity induced by food restriction and to explore the role of the HPA axis in this behaviour. Rats were randomly assigned to either an ad lib sedentary group (AL), a control wheel activity group (ACT), a food restriction‐induced hyperactivity group (FR‐ACT) group (1.5 h/day ad lib food, 22.5 h/day ad lib wheel access) or a pair‐fed group (FR). The BN and Lew rats reached the 25% body weight‐loss criterion of FR‐ACT (strain effect: F2,132 = 45.58, P 
ISSN:0953-8194
1365-2826
DOI:10.1111/j.1365-2826.2005.01367.x