The mechanism of CSF arrest in vertebrate oocytes

A cytoplasmic activity in mature oocytes responsible for second meiotic metaphase arrest was identified over 30 years ago in amphibian oocytes. In Xenopus oocytes cytostatic factor (CSF) activity is initiated by the progesterone-dependent synthesis of Mos, a MAPK kinase kinase that activates the MAP...

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Bibliographic Details
Published in:Molecular and cellular endocrinology 2002-02, Vol.187 (1), p.173-178
Main Authors: Maller, James L, Schwab, Markus S, Gross, Stefan D, Taieb, Frédéric E, Roberts, B.Tibor, Tunquist, Brian J
Format: Article
Language:English
Subjects:
Animals
Bub1
Cell Cycle - physiology
Cytostatic factor
Female
Humans
Life Sciences
MAP Kinase Signaling System - physiology
MAPK
Meiosis
Oocyte maturation
Oocytes - cytology
Oocytes - metabolism
Proto-Oncogene Proteins c-mos - physiology
Rsk
Spindle assembly checkpoint
Vertebrates - physiology
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Summary:A cytoplasmic activity in mature oocytes responsible for second meiotic metaphase arrest was identified over 30 years ago in amphibian oocytes. In Xenopus oocytes cytostatic factor (CSF) activity is initiated by the progesterone-dependent synthesis of Mos, a MAPK kinase kinase that activates the MAPK pathway. CSF arrest is mediated by a sole MAPK target, the protein kinase p90 Rsk. Rsk phosphorylates and activates the Bub1 protein kinase, which may cause metaphase arrest due to inhibition of the anaphase-promoting complex (APC) by a conserved mechanism defined genetically in yeast and mammalian cells. CSF arrest in vertebrate oocytes by p90 Rsk provides a link between the MAPK pathway and the spindle assembly checkpoint in the cell cycle.
ISSN:0303-7207
1872-8057
0303-7207
DOI:10.1016/S0303-7207(01)00695-5