The mechanism of CSF arrest in vertebrate oocytes

A cytoplasmic activity in mature oocytes responsible for second meiotic metaphase arrest was identified over 30 years ago in amphibian oocytes. In Xenopus oocytes cytostatic factor (CSF) activity is initiated by the progesterone-dependent synthesis of Mos, a MAPK kinase kinase that activates the MAP...

Full description

Saved in:
Bibliographic Details
Published in:Molecular and cellular endocrinology 2002-02, Vol.187 (1), p.173-178
Main Authors: Maller, James L, Schwab, Markus S, Gross, Stefan D, Taieb, Frédéric E, Roberts, B.Tibor, Tunquist, Brian J
Format: Article
Language:English
Subjects:
Animals
Bub1
Cell Cycle - physiology
Cytostatic factor
Female
Humans
Life Sciences
MAP Kinase Signaling System - physiology
MAPK
Meiosis
Oocyte maturation
Oocytes - cytology
Oocytes - metabolism
Proto-Oncogene Proteins c-mos - physiology
Rsk
Spindle assembly checkpoint
Vertebrates - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c461t-a8bcf5d3de6c34ac56be049b7ae512a1d8bfbba2cfc817c1fe012ca3e42fecf3
cites cdi_FETCH-LOGICAL-c461t-a8bcf5d3de6c34ac56be049b7ae512a1d8bfbba2cfc817c1fe012ca3e42fecf3
container_end_page 178
container_issue 1
container_start_page 173
container_title Molecular and cellular endocrinology
container_volume 187
creator Maller, James L
Schwab, Markus S
Gross, Stefan D
Taieb, Frédéric E
Roberts, B.Tibor
Tunquist, Brian J
description A cytoplasmic activity in mature oocytes responsible for second meiotic metaphase arrest was identified over 30 years ago in amphibian oocytes. In Xenopus oocytes cytostatic factor (CSF) activity is initiated by the progesterone-dependent synthesis of Mos, a MAPK kinase kinase that activates the MAPK pathway. CSF arrest is mediated by a sole MAPK target, the protein kinase p90 Rsk. Rsk phosphorylates and activates the Bub1 protein kinase, which may cause metaphase arrest due to inhibition of the anaphase-promoting complex (APC) by a conserved mechanism defined genetically in yeast and mammalian cells. CSF arrest in vertebrate oocytes by p90 Rsk provides a link between the MAPK pathway and the spindle assembly checkpoint in the cell cycle.
doi_str_mv 10.1016/S0303-7207(01)00695-5
format article
fullrecord <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_02679834v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0303720701006955</els_id><sourcerecordid>71677433</sourcerecordid><originalsourceid>FETCH-LOGICAL-c461t-a8bcf5d3de6c34ac56be049b7ae512a1d8bfbba2cfc817c1fe012ca3e42fecf3</originalsourceid><addsrcrecordid>eNqFkE1LAzEQhoMotn78BGVPoofVmWSzSU8ixS8oeLD3kM1OaKTb1WRb8N-7dUs9ehoYnved4WHsAuEWAcu7dxAgcsVBXQPeAJQTmcsDNkateK5BqkM23iMjdpLSBwAoyfUxGyFOtBZcjhnOF5Q15BZ2FVKTtT6bvj9lNkZKXRZW2YZiR1W0HWVt6747SmfsyNtlovPdPGXzp8f59CWfvT2_Th9muStK7HKrK-dlLWoqnSisk2VFUEwqZUkit1jryleV5c47jcqhJ0DurKCCe3JenLKboXZhl-YzhsbGb9PaYF4eZma7A16qiRbFBnv2amA_Y_u17j83TUiOlku7onadjMJSqUKIHpQD6GKbUiS_b0YwW63mV6vZOjOA5lerkX3ucndgXTVU_6V2HnvgfgCoN7IJFE1ygVaO6hDJdaZuwz8nfgAtGoac</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71677433</pqid></control><display><type>article</type><title>The mechanism of CSF arrest in vertebrate oocytes</title><source>ScienceDirect Freedom Collection</source><creator>Maller, James L ; Schwab, Markus S ; Gross, Stefan D ; Taieb, Frédéric E ; Roberts, B.Tibor ; Tunquist, Brian J</creator><creatorcontrib>Maller, James L ; Schwab, Markus S ; Gross, Stefan D ; Taieb, Frédéric E ; Roberts, B.Tibor ; Tunquist, Brian J</creatorcontrib><description>A cytoplasmic activity in mature oocytes responsible for second meiotic metaphase arrest was identified over 30 years ago in amphibian oocytes. In Xenopus oocytes cytostatic factor (CSF) activity is initiated by the progesterone-dependent synthesis of Mos, a MAPK kinase kinase that activates the MAPK pathway. CSF arrest is mediated by a sole MAPK target, the protein kinase p90 Rsk. Rsk phosphorylates and activates the Bub1 protein kinase, which may cause metaphase arrest due to inhibition of the anaphase-promoting complex (APC) by a conserved mechanism defined genetically in yeast and mammalian cells. CSF arrest in vertebrate oocytes by p90 Rsk provides a link between the MAPK pathway and the spindle assembly checkpoint in the cell cycle.</description><identifier>ISSN: 0303-7207</identifier><identifier>EISSN: 1872-8057</identifier><identifier>EISSN: 0303-7207</identifier><identifier>DOI: 10.1016/S0303-7207(01)00695-5</identifier><identifier>PMID: 11988325</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Animals ; Bub1 ; Cell Cycle - physiology ; Cytostatic factor ; Female ; Humans ; Life Sciences ; MAP Kinase Signaling System - physiology ; MAPK ; Meiosis ; Oocyte maturation ; Oocytes - cytology ; Oocytes - metabolism ; Proto-Oncogene Proteins c-mos - physiology ; Rsk ; Spindle assembly checkpoint ; Vertebrates - physiology</subject><ispartof>Molecular and cellular endocrinology, 2002-02, Vol.187 (1), p.173-178</ispartof><rights>2002 Elsevier Science Ireland Ltd</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c461t-a8bcf5d3de6c34ac56be049b7ae512a1d8bfbba2cfc817c1fe012ca3e42fecf3</citedby><cites>FETCH-LOGICAL-c461t-a8bcf5d3de6c34ac56be049b7ae512a1d8bfbba2cfc817c1fe012ca3e42fecf3</cites><orcidid>0000-0001-9612-2069</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,777,781,882,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11988325$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.inrae.fr/hal-02679834$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Maller, James L</creatorcontrib><creatorcontrib>Schwab, Markus S</creatorcontrib><creatorcontrib>Gross, Stefan D</creatorcontrib><creatorcontrib>Taieb, Frédéric E</creatorcontrib><creatorcontrib>Roberts, B.Tibor</creatorcontrib><creatorcontrib>Tunquist, Brian J</creatorcontrib><title>The mechanism of CSF arrest in vertebrate oocytes</title><title>Molecular and cellular endocrinology</title><addtitle>Mol Cell Endocrinol</addtitle><description>A cytoplasmic activity in mature oocytes responsible for second meiotic metaphase arrest was identified over 30 years ago in amphibian oocytes. In Xenopus oocytes cytostatic factor (CSF) activity is initiated by the progesterone-dependent synthesis of Mos, a MAPK kinase kinase that activates the MAPK pathway. CSF arrest is mediated by a sole MAPK target, the protein kinase p90 Rsk. Rsk phosphorylates and activates the Bub1 protein kinase, which may cause metaphase arrest due to inhibition of the anaphase-promoting complex (APC) by a conserved mechanism defined genetically in yeast and mammalian cells. CSF arrest in vertebrate oocytes by p90 Rsk provides a link between the MAPK pathway and the spindle assembly checkpoint in the cell cycle.</description><subject>Animals</subject><subject>Bub1</subject><subject>Cell Cycle - physiology</subject><subject>Cytostatic factor</subject><subject>Female</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>MAP Kinase Signaling System - physiology</subject><subject>MAPK</subject><subject>Meiosis</subject><subject>Oocyte maturation</subject><subject>Oocytes - cytology</subject><subject>Oocytes - metabolism</subject><subject>Proto-Oncogene Proteins c-mos - physiology</subject><subject>Rsk</subject><subject>Spindle assembly checkpoint</subject><subject>Vertebrates - physiology</subject><issn>0303-7207</issn><issn>1872-8057</issn><issn>0303-7207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNqFkE1LAzEQhoMotn78BGVPoofVmWSzSU8ixS8oeLD3kM1OaKTb1WRb8N-7dUs9ehoYnved4WHsAuEWAcu7dxAgcsVBXQPeAJQTmcsDNkateK5BqkM23iMjdpLSBwAoyfUxGyFOtBZcjhnOF5Q15BZ2FVKTtT6bvj9lNkZKXRZW2YZiR1W0HWVt6747SmfsyNtlovPdPGXzp8f59CWfvT2_Th9muStK7HKrK-dlLWoqnSisk2VFUEwqZUkit1jryleV5c47jcqhJ0DurKCCe3JenLKboXZhl-YzhsbGb9PaYF4eZma7A16qiRbFBnv2amA_Y_u17j83TUiOlku7onadjMJSqUKIHpQD6GKbUiS_b0YwW63mV6vZOjOA5lerkX3ucndgXTVU_6V2HnvgfgCoN7IJFE1ygVaO6hDJdaZuwz8nfgAtGoac</recordid><startdate>20020222</startdate><enddate>20020222</enddate><creator>Maller, James L</creator><creator>Schwab, Markus S</creator><creator>Gross, Stefan D</creator><creator>Taieb, Frédéric E</creator><creator>Roberts, B.Tibor</creator><creator>Tunquist, Brian J</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0001-9612-2069</orcidid></search><sort><creationdate>20020222</creationdate><title>The mechanism of CSF arrest in vertebrate oocytes</title><author>Maller, James L ; Schwab, Markus S ; Gross, Stefan D ; Taieb, Frédéric E ; Roberts, B.Tibor ; Tunquist, Brian J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c461t-a8bcf5d3de6c34ac56be049b7ae512a1d8bfbba2cfc817c1fe012ca3e42fecf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Bub1</topic><topic>Cell Cycle - physiology</topic><topic>Cytostatic factor</topic><topic>Female</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>MAP Kinase Signaling System - physiology</topic><topic>MAPK</topic><topic>Meiosis</topic><topic>Oocyte maturation</topic><topic>Oocytes - cytology</topic><topic>Oocytes - metabolism</topic><topic>Proto-Oncogene Proteins c-mos - physiology</topic><topic>Rsk</topic><topic>Spindle assembly checkpoint</topic><topic>Vertebrates - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maller, James L</creatorcontrib><creatorcontrib>Schwab, Markus S</creatorcontrib><creatorcontrib>Gross, Stefan D</creatorcontrib><creatorcontrib>Taieb, Frédéric E</creatorcontrib><creatorcontrib>Roberts, B.Tibor</creatorcontrib><creatorcontrib>Tunquist, Brian J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Molecular and cellular endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maller, James L</au><au>Schwab, Markus S</au><au>Gross, Stefan D</au><au>Taieb, Frédéric E</au><au>Roberts, B.Tibor</au><au>Tunquist, Brian J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The mechanism of CSF arrest in vertebrate oocytes</atitle><jtitle>Molecular and cellular endocrinology</jtitle><addtitle>Mol Cell Endocrinol</addtitle><date>2002-02-22</date><risdate>2002</risdate><volume>187</volume><issue>1</issue><spage>173</spage><epage>178</epage><pages>173-178</pages><issn>0303-7207</issn><eissn>1872-8057</eissn><eissn>0303-7207</eissn><abstract>A cytoplasmic activity in mature oocytes responsible for second meiotic metaphase arrest was identified over 30 years ago in amphibian oocytes. In Xenopus oocytes cytostatic factor (CSF) activity is initiated by the progesterone-dependent synthesis of Mos, a MAPK kinase kinase that activates the MAPK pathway. CSF arrest is mediated by a sole MAPK target, the protein kinase p90 Rsk. Rsk phosphorylates and activates the Bub1 protein kinase, which may cause metaphase arrest due to inhibition of the anaphase-promoting complex (APC) by a conserved mechanism defined genetically in yeast and mammalian cells. CSF arrest in vertebrate oocytes by p90 Rsk provides a link between the MAPK pathway and the spindle assembly checkpoint in the cell cycle.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>11988325</pmid><doi>10.1016/S0303-7207(01)00695-5</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-9612-2069</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 0303-7207
ispartof Molecular and cellular endocrinology, 2002-02, Vol.187 (1), p.173-178
issn 0303-7207
1872-8057
0303-7207
language eng
recordid cdi_hal_primary_oai_HAL_hal_02679834v1
source ScienceDirect Freedom Collection
subjects Animals
Bub1
Cell Cycle - physiology
Cytostatic factor
Female
Humans
Life Sciences
MAP Kinase Signaling System - physiology
MAPK
Meiosis
Oocyte maturation
Oocytes - cytology
Oocytes - metabolism
Proto-Oncogene Proteins c-mos - physiology
Rsk
Spindle assembly checkpoint
Vertebrates - physiology
title The mechanism of CSF arrest in vertebrate oocytes
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T14%3A54%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20mechanism%20of%20CSF%20arrest%20in%20vertebrate%20oocytes&rft.jtitle=Molecular%20and%20cellular%20endocrinology&rft.au=Maller,%20James%20L&rft.date=2002-02-22&rft.volume=187&rft.issue=1&rft.spage=173&rft.epage=178&rft.pages=173-178&rft.issn=0303-7207&rft.eissn=1872-8057&rft_id=info:doi/10.1016/S0303-7207(01)00695-5&rft_dat=%3Cproquest_hal_p%3E71677433%3C/proquest_hal_p%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c461t-a8bcf5d3de6c34ac56be049b7ae512a1d8bfbba2cfc817c1fe012ca3e42fecf3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=71677433&rft_id=info:pmid/11988325&rfr_iscdi=true