Cleft palate associated with an unbalanced karyotype in piglets sired by a heterozygous carrier boar with a balanced constitutional reciprocal translocation

The progeny of a commercial (Landrace x Duroc) x Large White boar contained a number of piglets with cleft palates. Chromosomal analyses of five affected piglets showed that they all had an identical unbalanced karyotype with partial monosomy of chromosome 16 and partial trisomy of chromosome 3, whe...

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Bibliographic Details
Published in:Veterinary record 2004-05, Vol.154 (21), p.659-661
Main Authors: Ducos, A., Pinton, A., Berland, H. M., Séguéla, A., Brun-Baronnat, C., Bonnet, N., Darré, R., Milan, D.
Format: Article
Language:English
Subjects:
Animals
Chromosome Aberrations
cleft palate
Cleft Palate - genetics
Cleft Palate - veterinary
Female
Karyotyping
Life Sciences
Male
piglets
Swine
Swine Diseases - genetics
Translocation, Genetic
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Summary:The progeny of a commercial (Landrace x Duroc) x Large White boar contained a number of piglets with cleft palates. Chromosomal analyses of five affected piglets showed that they all had an identical unbalanced karyotype with partial monosomy of chromosome 16 and partial trisomy of chromosome 3, whereas the normal piglets in the litters had balanced karyotypes. The chromosomal imbalance was the direct result of a constitutional balanced reciprocal translocation carried by their heterozygote sire, described, according to the standard nomenclature, as t(3;16)(q23;q22).
ISSN:0042-4900
2042-7670
DOI:10.1136/vr.154.21.659