Vaccenic acid metabolism in the liver of rat and bovine

Hepatic metabolism of vaccenic acid (VA), especially its conversion into CLA, was studied in the bovine (ruminant species that synthesizes CLA) and in the rat (model for nonruminant) by using the in vitro technique of liver explants. Liver tissue samples were collected from fed animals (5 male Wista...

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Bibliographic Details
Published in:Lipids 2005-03, Vol.40 (3), p.295-301
Main Authors: Gruffat, D, Torre, A. de la, Chardigny, J.M, Durand, D, Loreau, O, Bauchart, D
Format: Article
Language:English
Subjects:
Animal species
Animals
Biochemistry
Biochemistry, Molecular Biology
Biological Transport
Carbon dioxide
Cattle
conjugated linoleic acid
esterification
Esters - metabolism
Hepatocytes - metabolism
In Vitro Techniques
Life Sciences
lipid metabolism
Liver
Liver - metabolism
nutrient uptake
Oleic Acids - metabolism
oxidation
Oxidation-Reduction
Rats
vaccenic acid
very low density lipoprotein
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Summary:Hepatic metabolism of vaccenic acid (VA), especially its conversion into CLA, was studied in the bovine (ruminant species that synthesizes CLA) and in the rat (model for nonruminant) by using the in vitro technique of liver explants. Liver tissue samples were collected from fed animals (5 male Wistar rats and 5 Charolais steers) and incubated at 37°C for 17 h under an atmosphere of 95% O₂/5% CO₂ in medium supplemented with 0.75 mM of FA mixture and with 55 μM [1-¹⁴C]VA. VA uptake was about sixfold lower in bovine than in rat liver slices (P
ISSN:0024-4201
1558-9307
DOI:10.1007/s11745-005-1385-1