Central mediation of the effects of interleukin-1 on social exploration and body weight in mice

• Published in: Psychoneuroendocrinology 1997, Vol.22 (1), p.1-11
• Main Authors: Bluthé, Rose-Marie, Dantzer, Robert, Kelley, Keith W.
• Format: Article
• Language: English
• Subjects: Animals; Behavioral psychophysiology; Biological and medical sciences; Body weight; Body Weight - physiology; Brain - physiology; Energy Metabolism - physiology; Exploratory Behavior - physiology; Fundamental and applied biological sciences. Psychology; Humans; Immunology and behavior; Interleukin-1; Interleukin-1 - physiology; Interleukin-1 receptor antagonist; Life Sciences; Male; Mice; Mice, Inbred Strains; Mouse; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Receptor; Receptors, Interleukin-1 - physiology; Social Behavior
• ISSN: 0306-4530; 1873-3360
• DOI: 10.1016/S0306-4530(96)00042-X

To study the role of central IL-1 receptors in the effects of recombinant human IL-1β (IL-1β) on behavior and body weight, intracerebroventricular (ICV) injection of the specific antagonist of IL-1 receptors, IL-1ra, was administered to mice injected intraperitoneally (IP) and ICV with various doses of IL-1β. Doses of 500 ng IP IL-1β and 900 pg ICV IL-1β induced a comparable decrease in social behavior and loss of body weight. Pretreatment with IL-1ra (1.8 μg/mouse, ICV) blocked the effects of ICV IL-1β (900 pg/mouse) on social behavior. ICV IL-1ra (3.6 μg/mouse) also attenuated the effects of IP IL-1β (500 ng/mouse) on social behavior and change in body weight, suggesting that the effects of peripheral IL-1β are centrally mediated.