Blockade of brain type II interleukin-1 receptors potentiates IL1 β-induced anorexia in mice

Interleukin-1 β (IL1 β) peripheral activities are mediated by type I IL1 receptors (IL1RI), whereas type II IL1 receptors (IL1RII) act as `decoy' targets. To study the functionality of IL1RII in the brain, mice were treated with an intracerebroventricular injection of a neutralising MoAb direct...

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Bibliographic Details
Published in:Neuroscience letters 1998-04, Vol.246 (2), p.101-104
Main Authors: Cremona, Sandrine, Layé, Sophie, Dantzer, Robert, Parnet, Patricia
Format: Article
Language:English
Subjects:
Brain
Food intake
IL1 receptors
IL1 β
Life Sciences
Mouse
Rectal temperature
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Summary:Interleukin-1 β (IL1 β) peripheral activities are mediated by type I IL1 receptors (IL1RI), whereas type II IL1 receptors (IL1RII) act as `decoy' targets. To study the functionality of IL1RII in the brain, mice were treated with an intracerebroventricular injection of a neutralising MoAb directed against IL1RII (4E2, 1 μg) followed by recombinant rat IL1 β at a dose (2 ng) that produced a moderate but significant decrease of food intake 1 h 30 min after injection. The administration of 4E2 to IL-1 β treated mice significantly potentiated IL1 β-induced decrease in food intake without altering hypothermia. The effects of IL1 β were abrogated in the positive control group treated with IL1ra (2 μg, i.c.v). These results suggest that brain IL1RII down-regulate the effects of IL1 β on its cell targets in the brain.
ISSN:0304-3940
1872-7972
DOI:10.1016/S0304-3940(98)00238-9