Comparison of hepatic and renal drug-metabolising enzyme activities in sheep given single or two-fold challenge infections with Fasciola hepatica

The activity of drug-metabolising enzymes was compared in liver and kidneys of adult sheep given single or two-fold fluke infection. Fascioliasis was induced by oral administration of 200 metacercariae of Fasciola hepatica to female sheep either 10 or 20 weeks (mono-infections) or 10 and 20 weeks (b...

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Bibliographic Details
Published in:International journal for parasitology 2000-07, Vol.30 (8), p.953-958
Main Authors: Calléja, C, Bigot, K, Eeckhoutte, C, Sibille, P, Boulard, C, Galtier, P
Format: Article
Language:English
Subjects:
Animals
Benzphetamine - metabolism
Biological and medical sciences
Cytochrome P-450 Enzyme System - metabolism
Cytochrome P450
Ethylmorphine - metabolism
Experimental helminthic diseases. Models
Fasciola hepatica
Fasciola hepatica - pathogenicity
Fascioliasis - enzymology
Fascioliasis - parasitology
Fascioliasis - veterinary
Female
Glutathione transferase
Glutathione Transferase - metabolism
Helminthic diseases
Infectious diseases
Kidney - enzymology
Kidneys
Life Sciences
Liver
Liver - enzymology
Medical sciences
Microbiology and Parasitology
Multi-infection
Parasitic diseases
Sheep
Sheep Diseases - enzymology
Sheep Diseases - parasitology
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Summary:The activity of drug-metabolising enzymes was compared in liver and kidneys of adult sheep given single or two-fold fluke infection. Fascioliasis was induced by oral administration of 200 metacercariae of Fasciola hepatica to female sheep either 10 or 20 weeks (mono-infections) or 10 and 20 weeks (bi-infection) before killing. The parasitic pathology was ascertained at autopsy and by clinical observation of animals. In the liver of both mono- and bi-infected animals, significant decreases ( P
ISSN:0020-7519
1879-0135
DOI:10.1016/S0020-7519(00)00070-9