The evaluation of the role of CCK in the opioid modulation of the motility of the gastrointestinal tract in sheep

The participation of central cholecystokinin‐8 (CCK‐8) receptors in the modulatory effect of D‐Ala2, N‐Me‐Phe4, Gly5‐ol enkephalin (DAGO), a selective μ–opioid receptor agonist, on the spike burst activity of the gastrointestinal tract (rumen, reticulum, antrum, duodenum, colon and caecum) in sheep...

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Bibliographic Details
Published in:Journal of veterinary pharmacology and therapeutics 1999-04, Vol.22 (2), p.153-160
Main Authors: Kania, B F, Brikas, P, Buéno, L, Fioramonti, J, Zaremba-Rutkowska, M
Format: Article
Language:English
Subjects:
Animal biology
Animals
Benzodiazepinones - pharmacology
Cholecystokinin - physiology
Devazepide - pharmacology
Electromyography
Enkephalin, Ala-MePhe-Gly
Enkephalins - administration & dosage
Enkephalins - pharmacology
Female
Gastrointestinal Motility - drug effects
Injections, Intraventricular
Intestines - drug effects
Life Sciences
Narcotics - pharmacology
Phenylurea Compounds - pharmacology
Receptors, Cholecystokinin - drug effects
Receptors, Cholecystokinin - physiology
Receptors, Opioid, mu - agonists
Receptors, Opioid, mu - physiology
Sheep
Stomach - drug effects
Veterinary medicine and animal Health
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Summary:The participation of central cholecystokinin‐8 (CCK‐8) receptors in the modulatory effect of D‐Ala2, N‐Me‐Phe4, Gly5‐ol enkephalin (DAGO), a selective μ–opioid receptor agonist, on the spike burst activity of the gastrointestinal tract (rumen, reticulum, antrum, duodenum, colon and caecum) in sheep was investigated. DAGO was infused intracerebroventricularly (i.c.v.) at doses of 0.1–1 μg/kg body weight (BW).  It was shown that DAGO significantly inhibited myoelectrical activity of the wall of the forestomachs, abomasum and colon but stimulated this activity in the duodenum (rate of myoelectrical migrant complex‐MMC). The effects of DAGO were prevented by CCK‐8 antagonists (L‐364.718 and L‐365.260) previously infused at doses of 5–20 μg/kg BW.  The results of this present study indicate that central receptors of CCK‐8 participated in the modulatory action of an opioid on myoelectrical activity of the gastrointestinal tract in sheep. Furthermore, this result suggests that CCK‐8 is released in response to μ‐receptor stimulation, because CCK‐8 antagonists (L 364.718 and L 365.260) prevented the modulatory action of DAGO on the gastrointestinal motility in sheep.
ISSN:0140-7783
1365-2885
DOI:10.1046/j.1365-2885.1999.00190.x