Tryptic hydrolysis of caseinomacropeptide in membrane reactor : preparation of bioactive peptides

Tryptic hydrolysis of caseinomacropeptide (CMP: C-terminal part of k-Casein) was used as a model in membrane reactor to study continuous production and isolation of bioactive peptides from milk proteins. Compared to the batch reactor, productivity of the proposed continuous process was 3 times highe...

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Bibliographic Details
Published in:Biotechnology letters 1992-09, Vol.14 (9), p.805-810
Main Authors: BOUHALLAB, S, MOLLE, D, LEONIL, J
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biotechnology
Enzyme engineering
Fundamental and applied biological sciences. Psychology
Life Sciences
Methods. Procedures. Technologies
Miscellaneous
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Summary:Tryptic hydrolysis of caseinomacropeptide (CMP: C-terminal part of k-Casein) was used as a model in membrane reactor to study continuous production and isolation of bioactive peptides from milk proteins. Compared to the batch reactor, productivity of the proposed continuous process was 3 times higher after 3.5 hours of hydrolysis, but only 50% of the substrate is converted at steady state of the system. As shown by reverse-phase HPLC analysis, a good selectivity of the ultrafiltration membrane to various products was also obtained.
ISSN:0141-5492
1573-6776
DOI:10.1007/BF01029143