Changes in Substrate Metabolism and Effects of Excess Fatty Acids in Reperfused Myocardium

The purpose of these studies was to characterize the rates of fatty acid oxidation in reperfused myocardium and test the influence of excess fatty acids (FA) on mechanical function in the extracorporeally perfused, working swine heart model. Seventeen animals were prepared. Eight were untreated (LOW...

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Bibliographic Details
Published in:Circulation research 1988-03, Vol.62 (3), p.535-542
Main Authors: Liedtke, A James, DeMaison, Luc, Eggleston, Alice M, Cohen, Larry M, Nellis, Stephen H
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cardiology. Vascular system
Coronary Circulation
Coronary heart disease
Energy Metabolism
Fatty Acids - metabolism
Heart
Heart - physiology
Life Sciences
Medical sciences
Myocardium - metabolism
Oxidation-Reduction
Oxygen Consumption
Perfusion
Swine
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Summary:The purpose of these studies was to characterize the rates of fatty acid oxidation in reperfused myocardium and test the influence of excess fatty acids (FA) on mechanical function in the extracorporeally perfused, working swine heart model. Seventeen animals were prepared. Eight were untreated (LOW FA group; serum FA averaged 0.55 ± 0.07 μmol/ml) and nine received a constant infusion of 10% Intralipid with heparin to raise serum FA to about 1.4 ± 0.21 μmol/ml (HIGH FA group). Coronary flow in both groups was held at aerobic levels for an equilibration period of 40 minutes, acutely reduced regionally in the anterior descending circulation by 60% for 45 minutes, and acutely restored to aerobic levels for 60-minute reflow. Appreciable mechanical depression (-47 δ% from aerobic values; p
ISSN:0009-7330
1524-4571
DOI:10.1161/01.res.62.3.535