Percutaneous release of caffeine from microemulsion, emulsion and gel dosage forms

The transport of caffeine to the hypodermis by an alcohol-free o/w microemulsion was investigated and compared with an aqueous gel and an o/w emulsion. The microemulsion was well characterized and in vitro diffusion measurements through pig skin having the hypodermis either kept or removed were perf...

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Bibliographic Details
Published in:European journal of pharmaceutics and biopharmaceutics 2008-02, Vol.68 (2), p.446-451
Main Authors: Bolzinger, M.-A., Briançon, S., Pelletier, J., Fessi, H., Chevalier, Y.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Caffeine
Caffeine - chemistry
Caffeine - pharmacokinetics
Chemical Sciences
Dosage Forms
Emulsions
Female
Galenic pharmacology
General pharmacology
Hypodermis
Life Sciences
Male
Medical sciences
Microemulsion
or physical chemistry
Percutaneous penetration
Pharmaceutical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Skin - metabolism
Swine
Theoretical and
Topical delivery
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Summary:The transport of caffeine to the hypodermis by an alcohol-free o/w microemulsion was investigated and compared with an aqueous gel and an o/w emulsion. The microemulsion was well characterized and in vitro diffusion measurements through pig skin having the hypodermis either kept or removed were performed in static Franz cells. The microemulsion allowed delivery of a large fraction of the caffeine in the hypodermis: 23% of caffeine reached the hypodermis after 24 h diffusion, 1.3-fold larger than from the emulsion and gel dosage forms. Half this amount was stored in the hypodermis, the other half continuing its diffusion to the receptor compartment of the Franz cell.
ISSN:0939-6411
1873-3441
DOI:10.1016/j.ejpb.2007.10.018