The role of haemostasis in placenta-mediated complications

ABSTRACTNormal pregnancy is associated with an increasing state of activation of the haemostatic system. This activation state is excessive in women with placenta-mediated pregnancy complications (PMPCs), including preeclampsia (PE). Platelet activation plays a crucial pathophysiological role in PE....

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Bibliographic Details
Published in:Thrombosis research 2019-09, Vol.181 (Suppl. 1), p.S10-S14
Main Authors: Gris, Jean-Christophe, Bouvier, Sylvie, Cochery-Nouvellon, Éva, Mercier, Éric, Mousty, Ève, Pérez-Martin, Antonia
Format: Article
Language:English
Subjects:
Angiogenesis
Extracellular vesicles
Female
Haemostasis
Hematology
Hematology, Oncology, and Palliative Medicine
Hemostasis - physiology
Human health and pathology
Humans
Life Sciences
Placenta - pathology
Platelets
Pre-Eclampsia - blood
Preeclampsia
Pregnancy
Thrombin
Tissue factor
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Summary:ABSTRACTNormal pregnancy is associated with an increasing state of activation of the haemostatic system. This activation state is excessive in women with placenta-mediated pregnancy complications (PMPCs), including preeclampsia (PE). Platelet activation plays a crucial pathophysiological role in PE. The very early activation of coagulation in the intervillous space is mandatory for placental growth and morphogenesis but its excesses and/or inadequate control may participate to the emergence of the trophoblastic phenotype of PE. Extracellular vesicles, of endothelial but also of trophoblastic origin, can favour key cellular reactions of preeclampsia, acting as proactive cofactors. The understanding of this intricate relationship between haemostasis activation and PMPCs may provide interesting keys for new pathophysiological therapeutic developments.
ISSN:0049-3848
1879-2472
DOI:10.1016/S0049-3848(19)30359-7