Toxicokinetic and toxicodynamic of depleted uranium in the zebrafish, Danio rerio

•Waterborne U exposure at environmental level led to organ contamination.•U contamination in different tissues continued over the depuration period.•Genotoxicity of U was evidenced after both exposure and depuration periods.•U exposure led to severe biological damages in males. This study investigat...

Full description

Saved in:
Bibliographic Details
Published in:Aquatic toxicology 2018-04, Vol.197, p.9-18
Main Authors: Simon, Olivier, Gagnaire, Béatrice, Camilleri, Virginie, Cavalié, Isabelle, Floriani, Magali, Adam-Guillermin, Christelle
Format: Article
Language:English
Subjects:
Animals
Comet Assay
DNA - metabolism
DNA Damage
Female
Genotoxicity
Gills - drug effects
Gills - metabolism
Gonads - drug effects
Gonads - metabolism
Histopathology
Life Sciences
Male
Mutagenicity Tests
Ovary - drug effects
Ovary - pathology
Testis - drug effects
Testis - pathology
Testis - ultrastructure
Tissue Distribution - drug effects
Toxicodynamic
Toxicokinetics
Uranium
Uranium - toxicity
Water Pollutants, Chemical - toxicity
Water Pollutants, Radioactive - toxicity
Zebrafish
Zebrafish - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•Waterborne U exposure at environmental level led to organ contamination.•U contamination in different tissues continued over the depuration period.•Genotoxicity of U was evidenced after both exposure and depuration periods.•U exposure led to severe biological damages in males. This study investigated the accumulation pattern and biological effects (genotoxicity and histopathology) to adult zebrafish (male and female) exposed to a nominal waterborne concentration of 20 μg L−1 of depleted uranium (DU) for 28 days followed by 27 days of depuration. Accumulation pattern showed that (i) DU accumulated in brain, (ii) levels in digestive tract were higher than those measured in gills and (iii) levels remained high in kidney, brain and ovary despite the 27 days of depuration period. Genotoxicity, assessed by comet assay, was significant not only during DU exposure, but also during depuration phase. Gonads, in particular the testes, were more sensitive than gills. The histology of gonads indicated severe biological damages in males. This study improved knowledge of ecotoxic profile of uranium, for which a large range of biological effects has already been demonstrated.
ISSN:0166-445X
1879-1514
DOI:10.1016/j.aquatox.2017.12.013