The INSPIRE Research Initiative: A Program for GeroScience and Healthy Aging Research Going from Animal Models to Humans and the Healthcare System

Aging is the most important risk factor for the onset of several chronic diseases and functional decline. Understanding the interplays between biological aging and the biology of diseases and functional loss as well as integrating a function-centered approach to the care pathway of older adults are...

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Published in:The Journal of frailty & aging 2021, Vol.10 (2), p.86-93
Main Authors: de Souto Barreto, P, Guyonnet, S, Ader, I, Andrieu, S, Casteilla, L, Davezac, N, Dray, C, Fazilleau, N, Gourdy, P, Liblau, R, Parini, A, Payoux, P, Pénicaud, L, Rampon, C, Rolland, Y, Valet, P, Vergnolle, N, Vellas, B
Format: Article
Language:English
Subjects:
Age
Aged
Aging
Animal cognition
Animals
Biology
Biomarkers
Biomedical Research
Chronic illnesses
Delivery of Health Care
Disease prevention
Elaboration
Epidemiology
Frailty
Functional impairment
Geriatrics
Geriatry and gerontology
Gerontology
Health care
Health promotion
Healthy Aging
Human health and pathology
Humans
Immunology
Integrated care
Life Sciences
Manipulation
Medical imaging
Metabolic disorders
Models, Animal
Neuroimaging
Older people
Pathophysiology
Physiology
Prevention
Primary care
Public health
R&D
Research & development
Research centers
Sabatier, Paul (1854-1941)
Sarcopenia
Stem cells
Teams
Tomography
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container_issue 2
container_start_page 86
container_title The Journal of frailty & aging
container_volume 10
creator de Souto Barreto, P
Guyonnet, S
Ader, I
Andrieu, S
Casteilla, L
Davezac, N
Dray, C
Fazilleau, N
Gourdy, P
Liblau, R
Parini, A
Payoux, P
Pénicaud, L
Rampon, C
Rolland, Y
Valet, P
Vergnolle, N
Vellas, B
description Aging is the most important risk factor for the onset of several chronic diseases and functional decline. Understanding the interplays between biological aging and the biology of diseases and functional loss as well as integrating a function-centered approach to the care pathway of older adults are crucial steps towards the elaboration of preventive strategies (both pharmacological and non-pharmacological) against the onset and severity of burdensome chronic conditions during aging. In order to tackle these two crucial challenges, ie, how both the manipulation of biological aging and the implementation of a function-centered care pathway (the Integrated Care for Older People (ICOPE) model of the World Health Organization) may contribute to the trajectories of healthy aging, a new initiative on Gerosciences was built: the INSPIRE research program. The present article describes the scientific background on which the foundations of the INSPIRE program have been constructed and provides the general lines of this initiative that involves researchers from basic and translational science, clinical gerontology, geriatrics and primary care, and public health.
doi_str_mv 10.14283/jfa.2020.18
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ispartof The Journal of frailty & aging, 2021, Vol.10 (2), p.86-93
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subjects Age
Aged
Aging
Animal cognition
Animals
Biology
Biomarkers
Biomedical Research
Chronic illnesses
Delivery of Health Care
Disease prevention
Elaboration
Epidemiology
Frailty
Functional impairment
Geriatrics
Geriatry and gerontology
Gerontology
Health care
Health promotion
Healthy Aging
Human health and pathology
Humans
Immunology
Integrated care
Life Sciences
Manipulation
Medical imaging
Metabolic disorders
Models, Animal
Neuroimaging
Older people
Pathophysiology
Physiology
Prevention
Primary care
Public health
R&D
Research & development
Research centers
Sabatier, Paul (1854-1941)
Sarcopenia
Stem cells
Teams
Tomography
title The INSPIRE Research Initiative: A Program for GeroScience and Healthy Aging Research Going from Animal Models to Humans and the Healthcare System
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