Enantioselective Synthesis of Atropisomers with Multiple Stereogenic Axes

Atropisomers possessing multiple stereogenic axes are intriguing molecules with huge potential. However, only few approaches for their enantioselective synthesis are available due to the difficulties in assembling various stereogenic axes with high enantiocontrol. Only recently, innovative methods h...

Full description

Saved in:
Bibliographic Details
Published in:Angewandte Chemie International Edition 2020-07, Vol.59 (31), p.12623-12634
Main Authors: Bao, Xiaoze, Rodriguez, Jean, Bonne, Damien
Format: Article
Language:English
Subjects:
atropisomers
Axes (reference lines)
axial chirality
Chemical Sciences
Enantiomers
enantioselective catalysis
Organic chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Atropisomers possessing multiple stereogenic axes are intriguing molecules with huge potential. However, only few approaches for their enantioselective synthesis are available due to the difficulties in assembling various stereogenic axes with high enantiocontrol. Only recently, innovative methods have emerged, opening new possibilities for the synthesis of this original class of atropisomeric compounds. This Minireview describes the development of this field based on a classification of the multi‐axis systems according to the distance between the stereogenic axes and the strategy used to build them. Forging axes: Atropisomers with multiple stereogenic axes offer intriguing topologies in comparison to simple monoaxially chiral molecules. This Minireview covers some very recent breakthroughs in the enantioselective synthesis of atropisomers featuring multiple stereogenic axes.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.202002518