Preparation and cytotoxicity of lipid nanocarriers containing a hydrophobic flavanone

[Display omitted] Hesperetin is a flavanone with recognized biological activities. However, such activities are limited due to its restricted aqueous solubility and stability. In this regard, the main aim of this study was to develop and characterize lipid nanocarriers containing hesperetin. Nanostr...

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Published in:Colloids and surfaces. A, Physicochemical and engineering aspects Physicochemical and engineering aspects, 2020-09, Vol.601, p.124982, Article 124982
Main Authors: Simão, Daniele O., Honorato, Thalita D., Gobo, Graciely G., Piva, Henrique L., Goto, Patrícia L., Rolim, Larissa A., Turrin, Cédric-Olivier, Blanzat, Muriel, Tedesco, Antonio C., Siqueira-Moura, Marigilson P.
Format: Article
Language:English
Subjects:
Characterization
Chemical Sciences
Cytotoxicity
Glioblastoma
Hesperitin
Nanostructured lipid carriers
PIT method
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Summary:[Display omitted] Hesperetin is a flavanone with recognized biological activities. However, such activities are limited due to its restricted aqueous solubility and stability. In this regard, the main aim of this study was to develop and characterize lipid nanocarriers containing hesperetin. Nanostructured lipid carriers (NLC) were prepared using phase inversion temperature method and characterized by size, polydispersity index (PdI), zeta potential, physical stability, TEM analysis, encapsulation efficiency, in vitro release, and in vitro cytotoxic effect in cell line. Lipid nanocarriers presented diameter below 80 nm, narrow PdI (
ISSN:0927-7757
1873-4359
DOI:10.1016/j.colsurfa.2020.124982