Chemical profile, antiproliferative, antioxidant and enzyme inhibition activities of Ocimum basilicum L. and Pulicaria undulata (L.) C.A. Mey. grown in Sudan

•The essential oils from Ocimum basilicum and Pulicaria undulata were investigated.•Antioxidant, enzyme inhibitory and antiproliferative assays were performed.•Methyl chavicol and carvotanacetone were main components of the essential oils.•Methyl chavicol can be linked to observed tyrosinase inhibit...

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Published in:South African journal of botany 2020-08, Vol.132, p.403-409
Main Authors: Mohammed, Atif B.A., Yagi, Sakina, Tzanova, Tzvetomira, Schohn, Hervé, Abdelgadir, Haider, Stefanucci, Azzurra, Mollica, Adriano, Mahomoodally, Mohamad Fawzi, Adlan, Talal A., Zengin, Gökhan
Format: Article
Language:English
Subjects:
Antioxidant
Antiproliferative
Chemical profile
Enzyme inhibition
In silico study
Life Sciences
Ocimum basilicum
Phytopathology and phytopharmacy
Pulicaria undulata
Vegetal Biology
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Summary:•The essential oils from Ocimum basilicum and Pulicaria undulata were investigated.•Antioxidant, enzyme inhibitory and antiproliferative assays were performed.•Methyl chavicol and carvotanacetone were main components of the essential oils.•Methyl chavicol can be linked to observed tyrosinase inhibition ability.•The essential oils could be considered as promising theurapeutic agents. In the present study, essential oils extracted from the leafy stems of Ocimum basilicum (Family Lamiaceae) and Pulicaria undulata (Family Asteraceae) were investigated for their chemical profiles and biological activity including antioxidant, antiproliferative and enzyme inhibition activities. The chemical composition of essential oil was determined using Gas Chromatography-Mass Spectrometry. The antioxidant capacity was tested by scavenging of free radicals, reduction potential, chelating ability on ferrous ions and phosphomolybdenum assays. Cell viability was evaluated on human breast carcinoma (MCF7) and human colon adenocarcinoma (HT29 and HCT116) cell lines. Enzymatic activity was evaluated against α-glucosidase, α-amylase, acetylcholinesterase, butyrylcholinesterase, and tyrosinase. Based on the results obtained, in silico studies was performed to identify potential inhibitor of tyrosinase activity. Results showed that oil of O. basilicum was predominantly composed of methyl chavicol (51.9%) followed by linalool (20.0%). Oil of P. undulata was represented by oxygenated monoterpenes (96.9%) with carvotanacetone (92.1%) as the main molecule. Both oils exerted antioxidant activities with oil from P. undulata exerted significant (p
ISSN:0254-6299
1727-9321
DOI:10.1016/j.sajb.2020.06.006