Palladium-Catalyzed Asymmetric Allylic Alkylation of 4-Substituted Isoxazolidin-5-ones: Straightforward Access to β 2,2 -Amino Acids

We report here an unprecedented and highly enantioselective palladium-catalyzed allylic alkylation applied to 4-substituted isoxazolidin-5-ones. Ultimately, the process provides a straightforward access to β -amino acids bearing an all-carbon quaternary stereogenic center in great yields and a high...

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Bibliographic Details
Published in:Chemistry : a European journal 2018-04, Vol.24 (19), p.4810-4814
Main Authors: Nascimento de Oliveira, Marllon, Arseniyadis, Stellios, Cossy, Janine
Format: Article
Language:English
Subjects:
Chemical Sciences
Physics
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Summary:We report here an unprecedented and highly enantioselective palladium-catalyzed allylic alkylation applied to 4-substituted isoxazolidin-5-ones. Ultimately, the process provides a straightforward access to β -amino acids bearing an all-carbon quaternary stereogenic center in great yields and a high degree of enantioselectivity.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201800641