Synthesis, crystal structure and biological studies of novel amidrazones, triazoles, Thiatriazole and Triazine compounds

A series of Amidrazones, Triazoles, Thiatriazole and Triazine derivatives was synthesized, and their antibacterial and antioxidant activities were evaluated. Biological screening showed that the majority of the compounds possess a moderate antibacterial activity and a significant antioxidant effects....

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Bibliographic Details
Published in:Journal of molecular structure 2020-08, Vol.1214, p.128209, Article 128209
Main Authors: Ben Salem, Adel, Ben Salah, Bochra, Mhalla, Dhekra, Trigui, Mohamed, Mourer, Maxime, Regnouf-de-Vains, Jean -Bernard, Kossentini, Mohamed
Format: Article
Language:English
Subjects:
Amidrazones
Antibacterial activity
Antioxidant activity
Chemical Sciences
Medicinal Chemistry
Organic chemistry
Thiatriazole
Triazine
Triazoles
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Summary:A series of Amidrazones, Triazoles, Thiatriazole and Triazine derivatives was synthesized, and their antibacterial and antioxidant activities were evaluated. Biological screening showed that the majority of the compounds possess a moderate antibacterial activity and a significant antioxidant effects. In order to further research the compound 3a, the crystal structure was detected by X-ray diffraction. Meanwhile, the structural assignments of the new products were done on the basis of IR, 1H NMR, 13C NMR, elemental analysis and HRMS (ESI) spectroscopy. [Display omitted] •A series of Amidrazones, Triazoles, Thiatriazole and Triazine derivatives was synthesized.•Their antibacterial and antioxidant activities were evaluated.•Biological screening showed that the majority of the compounds possess a moderate antibacterial activity and a significant antioxidant effects.
ISSN:0022-2860
1872-8014
0022-2860
DOI:10.1016/j.molstruc.2020.128209