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Synthesis, crystal structure and biological studies of novel amidrazones, triazoles, Thiatriazole and Triazine compounds
A series of Amidrazones, Triazoles, Thiatriazole and Triazine derivatives was synthesized, and their antibacterial and antioxidant activities were evaluated. Biological screening showed that the majority of the compounds possess a moderate antibacterial activity and a significant antioxidant effects....
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| Published in: | Journal of molecular structure 2020-08, Vol.1214, p.128209, Article 128209 |
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| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c346t-5e3cf2147ee2d0af9c0c4d2e9f1c4bd6a1dfdc379bc4dfc6a8248ba7e095c72c3 |
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| cites | cdi_FETCH-LOGICAL-c346t-5e3cf2147ee2d0af9c0c4d2e9f1c4bd6a1dfdc379bc4dfc6a8248ba7e095c72c3 |
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| container_issue | |
| container_start_page | 128209 |
| container_title | Journal of molecular structure |
| container_volume | 1214 |
| creator | Ben Salem, Adel Ben Salah, Bochra Mhalla, Dhekra Trigui, Mohamed Mourer, Maxime Regnouf-de-Vains, Jean -Bernard Kossentini, Mohamed |
| description | A series of Amidrazones, Triazoles, Thiatriazole and Triazine derivatives was synthesized, and their antibacterial and antioxidant activities were evaluated. Biological screening showed that the majority of the compounds possess a moderate antibacterial activity and a significant antioxidant effects. In order to further research the compound 3a, the crystal structure was detected by X-ray diffraction. Meanwhile, the structural assignments of the new products were done on the basis of IR, 1H NMR, 13C NMR, elemental analysis and HRMS (ESI) spectroscopy.
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•A series of Amidrazones, Triazoles, Thiatriazole and Triazine derivatives was synthesized.•Their antibacterial and antioxidant activities were evaluated.•Biological screening showed that the majority of the compounds possess a moderate antibacterial activity and a significant antioxidant effects. |
| doi_str_mv | 10.1016/j.molstruc.2020.128209 |
| format | article |
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[Display omitted]
•A series of Amidrazones, Triazoles, Thiatriazole and Triazine derivatives was synthesized.•Their antibacterial and antioxidant activities were evaluated.•Biological screening showed that the majority of the compounds possess a moderate antibacterial activity and a significant antioxidant effects.</description><identifier>ISSN: 0022-2860</identifier><identifier>EISSN: 1872-8014</identifier><identifier>EISSN: 0022-2860</identifier><identifier>DOI: 10.1016/j.molstruc.2020.128209</identifier><language>eng</language><publisher>Elsevier B.V</publisher><subject>Amidrazones ; Antibacterial activity ; Antioxidant activity ; Chemical Sciences ; Medicinal Chemistry ; Organic chemistry ; Thiatriazole ; Triazine ; Triazoles</subject><ispartof>Journal of molecular structure, 2020-08, Vol.1214, p.128209, Article 128209</ispartof><rights>2020 Elsevier B.V.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c346t-5e3cf2147ee2d0af9c0c4d2e9f1c4bd6a1dfdc379bc4dfc6a8248ba7e095c72c3</citedby><cites>FETCH-LOGICAL-c346t-5e3cf2147ee2d0af9c0c4d2e9f1c4bd6a1dfdc379bc4dfc6a8248ba7e095c72c3</cites><orcidid>0000-0001-5272-4527</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://hal.science/hal-02954982$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Ben Salem, Adel</creatorcontrib><creatorcontrib>Ben Salah, Bochra</creatorcontrib><creatorcontrib>Mhalla, Dhekra</creatorcontrib><creatorcontrib>Trigui, Mohamed</creatorcontrib><creatorcontrib>Mourer, Maxime</creatorcontrib><creatorcontrib>Regnouf-de-Vains, Jean -Bernard</creatorcontrib><creatorcontrib>Kossentini, Mohamed</creatorcontrib><title>Synthesis, crystal structure and biological studies of novel amidrazones, triazoles, Thiatriazole and Triazine compounds</title><title>Journal of molecular structure</title><description>A series of Amidrazones, Triazoles, Thiatriazole and Triazine derivatives was synthesized, and their antibacterial and antioxidant activities were evaluated. Biological screening showed that the majority of the compounds possess a moderate antibacterial activity and a significant antioxidant effects. In order to further research the compound 3a, the crystal structure was detected by X-ray diffraction. Meanwhile, the structural assignments of the new products were done on the basis of IR, 1H NMR, 13C NMR, elemental analysis and HRMS (ESI) spectroscopy.
[Display omitted]
•A series of Amidrazones, Triazoles, Thiatriazole and Triazine derivatives was synthesized.•Their antibacterial and antioxidant activities were evaluated.•Biological screening showed that the majority of the compounds possess a moderate antibacterial activity and a significant antioxidant effects.</description><subject>Amidrazones</subject><subject>Antibacterial activity</subject><subject>Antioxidant activity</subject><subject>Chemical Sciences</subject><subject>Medicinal Chemistry</subject><subject>Organic chemistry</subject><subject>Thiatriazole</subject><subject>Triazine</subject><subject>Triazoles</subject><issn>0022-2860</issn><issn>1872-8014</issn><issn>0022-2860</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqFkE9PwzAMxSMEEmPwFVCvSHQkadc_N6YJGNIkDoxzlDoOy9Q2U9JNjE9PujKunGw_-_ckP0JuGZ0wyrKHzaSxte_cDiac8iDygtPyjIxYkfO4oCw9JyNKOY95kdFLcuX9hlLKAjwiX--HtlujN_4-Anfwnayjo1e3cxjJVkWVsbX9NHBc7JRBH1kdtXaPdSQbo5z8ti0GvHMmtHXfrtZGnsajyaofTIsR2GZrd63y1-RCy9rjzW8dk4_np9V8ES_fXl7ns2UMSZp18RQT0JylOSJXVOoSKKSKY6kZpJXKJFNaQZKXVZA1ZLLgaVHJHGk5hZxDMiZ3g-9a1mLrTCPdQVhpxGK2FL1GeTlNy4LvWbjNhltw1nuH-g9gVPRZi404ZS36rMWQdQAfBxDDJ3uDTngw2AIq4xA6oaz5z-IHPPGPrQ</recordid><startdate>20200815</startdate><enddate>20200815</enddate><creator>Ben Salem, Adel</creator><creator>Ben Salah, Bochra</creator><creator>Mhalla, Dhekra</creator><creator>Trigui, Mohamed</creator><creator>Mourer, Maxime</creator><creator>Regnouf-de-Vains, Jean -Bernard</creator><creator>Kossentini, Mohamed</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>AAYXX</scope><scope>CITATION</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0001-5272-4527</orcidid></search><sort><creationdate>20200815</creationdate><title>Synthesis, crystal structure and biological studies of novel amidrazones, triazoles, Thiatriazole and Triazine compounds</title><author>Ben Salem, Adel ; Ben Salah, Bochra ; Mhalla, Dhekra ; Trigui, Mohamed ; Mourer, Maxime ; Regnouf-de-Vains, Jean -Bernard ; Kossentini, Mohamed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c346t-5e3cf2147ee2d0af9c0c4d2e9f1c4bd6a1dfdc379bc4dfc6a8248ba7e095c72c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Amidrazones</topic><topic>Antibacterial activity</topic><topic>Antioxidant activity</topic><topic>Chemical Sciences</topic><topic>Medicinal Chemistry</topic><topic>Organic chemistry</topic><topic>Thiatriazole</topic><topic>Triazine</topic><topic>Triazoles</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ben Salem, Adel</creatorcontrib><creatorcontrib>Ben Salah, Bochra</creatorcontrib><creatorcontrib>Mhalla, Dhekra</creatorcontrib><creatorcontrib>Trigui, Mohamed</creatorcontrib><creatorcontrib>Mourer, Maxime</creatorcontrib><creatorcontrib>Regnouf-de-Vains, Jean -Bernard</creatorcontrib><creatorcontrib>Kossentini, Mohamed</creatorcontrib><collection>CrossRef</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Journal of molecular structure</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ben Salem, Adel</au><au>Ben Salah, Bochra</au><au>Mhalla, Dhekra</au><au>Trigui, Mohamed</au><au>Mourer, Maxime</au><au>Regnouf-de-Vains, Jean -Bernard</au><au>Kossentini, Mohamed</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis, crystal structure and biological studies of novel amidrazones, triazoles, Thiatriazole and Triazine compounds</atitle><jtitle>Journal of molecular structure</jtitle><date>2020-08-15</date><risdate>2020</risdate><volume>1214</volume><spage>128209</spage><pages>128209-</pages><artnum>128209</artnum><issn>0022-2860</issn><eissn>1872-8014</eissn><eissn>0022-2860</eissn><abstract>A series of Amidrazones, Triazoles, Thiatriazole and Triazine derivatives was synthesized, and their antibacterial and antioxidant activities were evaluated. Biological screening showed that the majority of the compounds possess a moderate antibacterial activity and a significant antioxidant effects. In order to further research the compound 3a, the crystal structure was detected by X-ray diffraction. Meanwhile, the structural assignments of the new products were done on the basis of IR, 1H NMR, 13C NMR, elemental analysis and HRMS (ESI) spectroscopy.
[Display omitted]
•A series of Amidrazones, Triazoles, Thiatriazole and Triazine derivatives was synthesized.•Their antibacterial and antioxidant activities were evaluated.•Biological screening showed that the majority of the compounds possess a moderate antibacterial activity and a significant antioxidant effects.</abstract><pub>Elsevier B.V</pub><doi>10.1016/j.molstruc.2020.128209</doi><orcidid>https://orcid.org/0000-0001-5272-4527</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-2860 |
| ispartof | Journal of molecular structure, 2020-08, Vol.1214, p.128209, Article 128209 |
| issn | 0022-2860 1872-8014 0022-2860 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_02954982v1 |
| source | ScienceDirect Freedom Collection |
| subjects | Amidrazones Antibacterial activity Antioxidant activity Chemical Sciences Medicinal Chemistry Organic chemistry Thiatriazole Triazine Triazoles |
| title | Synthesis, crystal structure and biological studies of novel amidrazones, triazoles, Thiatriazole and Triazine compounds |
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