Study of physical interactions of fluorescein-containing amphiphilic copolyesters with albumin in aqueous dispersions

• Published in: Applied nanoscience 2020-08, Vol.10 (8), p.2655-2663
• Main Authors: Yakoviv, M. V., Nosova, N. G., Samaryk, V. Y., Pasetto, P., Varvarenko, S. M.
• Format: Article
• Language: English
• Subjects: Albumins; Biochemistry; Biochemistry, Molecular Biology; Biological activity; Biomedical materials; Biotechnology; Chemical Sciences; Chemistry and Materials Science; Drug delivery systems; Fluorescein; Fluorescence; Food and Nutrition; Life Sciences; Material chemistry; Materials Science; Membrane Biology; Nanochemistry; Nanoparticles; Nanotechnology; Nanotechnology and Microengineering; Original Article; Polymers; Proteins
• ISSN: 2190-5509; 2190-5517
• DOI: 10.1007/s13204-019-00987-6

In recent years, a significant progress has been made in the development and study of nanoparticles aimed at biomedical applications. Polymer systems are believed to be an interesting perspective in this direction, because they can be designed as multifunctional systems for drug delivery and release, as well as they can provide information about their location using fluorescence spectroscopy methods. The nanoparticles get directly into the bloodstream through intravenous injections. In most cases, the first molecules which they interact are proteins, which are one of the main constituents of the human body and the driving force of most biological processes. Therefore, understanding the interaction between nanoparticles and proteins is important for the safe and effective use of nanoparticles. In this regard, changes in the properties of nanoparticles after interaction with albumin have been analyzed and it has been shown that albumin, depending on the structure of the amphiphilic copolyester, either acts as an additional stabilizer of nanoparticles dispersed phase or leads to partial aggregation. At the same time, the albumin layer slightly affects the characteristics of biodistribution and the hydrolytic properties of the obtained amphiphilic copolyesters with fluorescent moieties.