Pubertal outcomes of children transplanted with allogeneic stem cells after myeloablative total body irradiation or busulfan: Influence of age and sex is confirmed, while a role of chronic graft‐versus‐host disease in delayed puberty onset is revealed

Introduction Myeloablative conditioning before allogeneic HSCT during childhood exposes to serious long‐term complications, especially gonadal dysfunction. Pubertal issues are less described than other post‐HSCT sequelae in childhood. Methods Pubertal development and biological gonadal parameters we...

Full description

Saved in:
Bibliographic Details
Published in:Pediatric transplantation 2020-09, Vol.24 (6), p.e13773-n/a
Main Authors: Weinhard, Sara, Wiedemann, Arnaud, Leheup, Bruno, Dalle, Jean‐Hugues, Lebon Labich, Béatrice, Pochon, Cécile
Format: Article
Language:English
Subjects:
Age
Busulfan
Children
Children & youth
Complications
female sex
Graft versus host disease
Graft-versus-host reaction
hematopoietic stem cell transplantation
Human health and pathology
Leukemia
Life Sciences
Multivariate analysis
myeloablative conditioning regimen
Pediatrics
Physical growth
pubertal development
Puberty
Radiation
Sex
Stem cell transplantation
Toxicity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Introduction Myeloablative conditioning before allogeneic HSCT during childhood exposes to serious long‐term complications, especially gonadal dysfunction. Pubertal issues are less described than other post‐HSCT sequelae in childhood. Methods Pubertal development and biological gonadal parameters were assessed in a retrospective monocentric cohort of prepubertal patients who underwent HSCT after myeloablative conditioning with TBI or busulfan between 1981 and 2017. Results Seventy‐four patients (28 girls and 46 boys) were included. No spontaneous pubertal development was found in 50% of girls and 10% of boys (P 10 years (P = .031). Conclusion This study highlighted the toxicity of MAC in prepubescent children: TBI did worse, but this was especially true for the most susceptible patients (girls, leukemic patients, and patients older than 10 years). It suggests a possible role of GVHD in delayed puberty.
ISSN:1397-3142
1399-3046
DOI:10.1111/petr.13773