Accessing p‐Hydroxycinnamic Acids: Chemical Synthesis, Biomass Recovery, or Engineered Microbial Production?

p‐Hydroxycinnamic acids (i. e., p‐coumaric, ferulic, sinapic, and caffeic acids) are phenolic compounds involved in the biosynthesis pathway of lignin. These naturally occurring molecules not only exhibit numerous attractive properties, such as antioxidant, anti‐UV, and anticancer activities, but th...

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Bibliographic Details
Published in:ChemSusChem 2021-01, Vol.14 (1), p.118-129
Main Authors: Flourat, Amandine L., Combes, Jeanne, Bailly‐Maitre‐Grand, Claire, Magnien, Kévin, Haudrechy, Arnaud, Renault, Jean‐Hugues, Allais, Florent
Format: Article
Language:English
Subjects:
Acids
Additives
Anticancer properties
Antioxidants
Bioconversion
Biomass
Biosynthesis
Biotechnology
caffeic acid
Chemical and Process Engineering
Chemical Sciences
Chemical synthesis
coumaric acid
Engineering Sciences
Ferulic acid
Hydroxycinnamic acid
Life Sciences
Lignocellulose
Microorganisms
Organic chemistry
p-hydroxycinnamic acid
Phenols
Polymers
Production costs
sinapic acid
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Summary:p‐Hydroxycinnamic acids (i. e., p‐coumaric, ferulic, sinapic, and caffeic acids) are phenolic compounds involved in the biosynthesis pathway of lignin. These naturally occurring molecules not only exhibit numerous attractive properties, such as antioxidant, anti‐UV, and anticancer activities, but they also have been used as building blocks for the synthesis of tailored monomers and functional additives for the food/feed, cosmetic, and plastics sectors. Despite their numerous high value‐added applications, the sourcing of p‐hydroxycinnamic acids is not ensured at the industrial scale except for ferulic acid, and their production cost remains too high for commodity applications. These compounds can be either chemically synthesized or extracted from lignocellulosic biomass, and recently their production through bioconversion emerged. Herein the different strategies described in the literature to produce these valuable molecules are discussed. Make a choice: p‐Hydroxycinnamic acids are of wide interest for various markets. Currently, their availability remains limited. Herein, an overview of the different strategies for (1) their synthesis through eco‐compatible process, (2) their extraction from agricultural co‐product, and (3) their bioproduction, is given and discussed.
ISSN:1864-5631
1864-564X
DOI:10.1002/cssc.202002141