Synthesis of gemini triethylene-tetramine bridged bis-tridentate iron(III) chelators

Eight gemini bis-2-(2-hydroxyphenyl)-thiazole-4-carboxamide and -thiocarboxamide (BHPTC) chelators were efficiently synthesized. Mass spectrometry showed these compounds all form 1:1 complexes with iron(III). Three of these chelators exhibit promising antiproliferative activities when tested on huma...

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Bibliographic Details
Published in:Tetrahedron 2011-03, Vol.67 (11), p.2149-2154
Main Authors: Rodriguez-Lucena, David, Schalk, Isabelle J., Mislin, Gaëtan L.A.
Format: Article
Language:English
Subjects:
Antineoplastic agents
Antiproliferatives
BHPTC
Biological and medical sciences
Biotechnology
Cancer
Chelating
Chemical Sciences
Chemistry
Exact sciences and technology
General aspects
Heterocyclic compounds
Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms
Human
Iron chelation therapy
Iron chelator
Mass spectrometry
Medical sciences
Medicinal Chemistry
Organic chemistry
Pharmacology. Drug treatments
Preparations and properties
Synthesis (chemistry)
Tetrahedrons
Thioamide
Triethylene-tetramine
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Summary:Eight gemini bis-2-(2-hydroxyphenyl)-thiazole-4-carboxamide and -thiocarboxamide (BHPTC) chelators were efficiently synthesized. Mass spectrometry showed these compounds all form 1:1 complexes with iron(III). Three of these chelators exhibit promising antiproliferative activities when tested on human cancerous cell lines. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2011.01.008