TP53 codon 72 polymorphism, p53 expression, and 1p/19q status in oligodendroglial tumors

Abstract The functional single-nucleotide polymorphism (SNP) in codon 72 of TP53 has been shown to be both a risk factor and a prognostic biomarker in various cancers. Such results were also reported in brain tumors, notably in astrocytomas. This SNP has never been precisely investigated in oligoden...

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Bibliographic Details
Published in:Cancer genetics and cytogenetics 2007-09, Vol.177 (2), p.103-107
Main Authors: Idbaih, Ahmed, Boisselier, Blandine, Marie, Yannick, El Hallani, Soufiane, Sanson, Marc, Crinière, Emmanuelle, Rodero, Mathieu, Carpentier, Catherine, Paris, Sophie, Laigle-Donadey, Florence, Ducray, François, Hoang-Xuan, Khê, Delattre, Jean-Yves
Format: Article
Language:English
Subjects:
Adult
Aged
Astrocytoma - genetics
Astrocytoma - metabolism
Brain Neoplasms - genetics
Brain Neoplasms - metabolism
Case-Control Studies
Chromosomes, Human, Pair 1 - genetics
Codon
DNA, Neoplasm - blood
DNA, Neoplasm - genetics
DNA, Neoplasm - metabolism
Female
Genotype
Glioma - genetics
Glioma - metabolism
Hematology, Oncology and Palliative Medicine
Humans
Immunoenzyme Techniques
Life Sciences
Male
Medical Education
Microsatellite Repeats
Middle Aged
Oligodendroglioma - genetics
Oligodendroglioma - metabolism
Polymorphism, Genetic - genetics
Prognosis
Survival Rate
Tumor Suppressor Protein p53 - genetics
Tumor Suppressor Protein p53 - metabolism
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Summary:Abstract The functional single-nucleotide polymorphism (SNP) in codon 72 of TP53 has been shown to be both a risk factor and a prognostic biomarker in various cancers. Such results were also reported in brain tumors, notably in astrocytomas. This SNP has never been precisely investigated in oligodendroglial tumors. We retrospectively analyzed blood samples of 275 oligodendroglial tumor patients for the TP53 codon 72 polymorphism and compared them with a series of 144 healthy controls. Arg/Arg, Arg/Pro, and Pro/Pro genotypes were found in 54.2 versus 60.4%, 39.3 versus 34.0%, and 7.3 versus 5.6% of patients and controls, respectively. This suggests no association between oligodendroglial tumors and the SNP in codon 72 of TP53 . Similarly, no correlation was found among the TP53 codon 72 polymorphism and prognosis, p53 expression, and chromosomes 1p and 19q status.
ISSN:0165-4608
1873-4456
DOI:10.1016/j.cancergencyto.2007.06.010