Chiral Transient Directing Groups in Transition-Metal-Catalyzed Enantioselective C–H Bond Functionalization

Transition-metal-catalyzed C–H bond functionalization has known a rapid evolution in the last years, offering modern strategies for reaching high molecular complexity in a step- and atom-economical way. Despite the indisputable advances, selectivity issues still remain, given the ubiquity of C–H bon...

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Bibliographic Details
Published in:ACS catalysis 2020-11, Vol.10 (21), p.12898-12919
Main Authors: Lapuh, Maria I, Mazeh, Sara, Besset, Tatiana
Format: Article
Language:English
Subjects:
Chemical Sciences
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Summary:Transition-metal-catalyzed C–H bond functionalization has known a rapid evolution in the last years, offering modern strategies for reaching high molecular complexity in a step- and atom-economical way. Despite the indisputable advances, selectivity issues still remain, given the ubiquity of C–H bonds on molecules; thus, several approaches have been developed to tackle this challenge. Among them, the use of a transient directing group has emerged as an effective tool, circumventing the need for extra synthetic steps to install and then cleave a directing group on the molecule. More recently, this strategy has been successfully applied to the even more challenging transition-metal-catalyzed enantioselective C–H bond functionalization. This review will highlight and discuss the main advances made in the use of a chiral transient directing group for the enantioselective functionalization of C­(sp2)–H and C­(sp3)–H bonds by transition-metal catalysis.
ISSN:2155-5435
2155-5435
DOI:10.1021/acscatal.0c03317