Chromosome dynamics during interphase: a biophysical perspective

The dynamic nature of chromosome organization plays a central role in the regulation of many crucial processes, such as DNA transcription and replication. However, the molecular bases of the link between genomic function, structure and dynamics remain elusive. In this review, we focus on how biophys...

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Bibliographic Details
Published in:Current opinion in genetics & development 2020-04, Vol.61, p.37-43
Main Authors: Tortora, Maxime MC, Salari, Hossein, Jost, Daniel
Format: Article
Language:English
Subjects:
Biological Physics
Physics
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Summary:The dynamic nature of chromosome organization plays a central role in the regulation of many crucial processes, such as DNA transcription and replication. However, the molecular bases of the link between genomic function, structure and dynamics remain elusive. In this review, we focus on how biophysical modelling can be instrumentally used to rationalize experimental studies of chromosome dynamics, and to probe the impact of putative mechanisms on genome folding kinetics during interphase. We introduce the general connection between chromatin internal organization and dynamics, and outline the potential effects of passive interactions mediated by architectural proteins and of active, energy-dependent processes on chromatin motion. Finally, we discuss current ambiguities emerging from in vivo observations, in particular related to ATP depletion and transcriptional activation, and highlight future perspectives.
ISSN:0959-437X
1879-0380
DOI:10.1016/j.gde.2020.03.001