ASB-2 Inhibits Growth and Promotes Commitment in Myeloid Leukemia Cells

In acute promyelocytic leukemia (APL) cells harboring the promyelocytic leukemia retinoic acid receptor α (PML-RARα) chimeric protein, retinoic acid (RA)-induced differentiation is triggered through a PML-RARα signaling resulting in activation of critical target genes. Induced differentiation of APL...

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Published in:The Journal of biological chemistry 2002-01, Vol.277 (1), p.218-224
Main Authors: Guibal, Florence C., Moog-Lutz, Christel, Smolewski, Piotr, Di Gioia, Yolande, Darzynkiewicz, Zbigniew, Lutz, Pierre G., Cayre, Yvon E.
Format: Article
Language:English
Subjects:
Adaptor Proteins, Signal Transducing
Amino Acid Sequence
Base Sequence
Carrier Proteins - genetics
Carrier Proteins - physiology
Cell Differentiation - drug effects
Chromatin - metabolism
Humans
Leukemia, Promyelocytic, Acute - pathology
Life Sciences
Molecular Sequence Data
Neoplasm Proteins - physiology
Oncogene Proteins, Fusion - physiology
RNA, Messenger - analysis
Suppressor of Cytokine Signaling Proteins
Tretinoin - pharmacology
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cited_by cdi_FETCH-LOGICAL-c506t-9593015d51f1789214709cc8731907e6afe70620d304c4b0a17896b19f52584a3
cites cdi_FETCH-LOGICAL-c506t-9593015d51f1789214709cc8731907e6afe70620d304c4b0a17896b19f52584a3
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container_title The Journal of biological chemistry
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creator Guibal, Florence C.
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description In acute promyelocytic leukemia (APL) cells harboring the promyelocytic leukemia retinoic acid receptor α (PML-RARα) chimeric protein, retinoic acid (RA)-induced differentiation is triggered through a PML-RARα signaling resulting in activation of critical target genes. Induced differentiation of APL cells is always preceded by withdrawal from the cell cycle and commitment events leading to terminal differentiation. Here we have identified the human ankyrin repeat-containing protein with a suppressor of cytokine signaling box-2 (ASB-2) cDNA, as a novel RA-induced gene in APL cells. PML-RARα strongly enhanced RA-induced ASB-2 mRNA expression. In myeloid leukemia cells, ASB-2 expression induced growth inhibition and chromatin condensation recapitulating early events critical to RA-induced differentiation of APL cells.
doi_str_mv 10.1074/jbc.M108476200
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subjects Adaptor Proteins, Signal Transducing
Amino Acid Sequence
Base Sequence
Carrier Proteins - genetics
Carrier Proteins - physiology
Cell Differentiation - drug effects
Chromatin - metabolism
Humans
Leukemia, Promyelocytic, Acute - pathology
Life Sciences
Molecular Sequence Data
Neoplasm Proteins - physiology
Oncogene Proteins, Fusion - physiology
RNA, Messenger - analysis
Suppressor of Cytokine Signaling Proteins
Tretinoin - pharmacology
title ASB-2 Inhibits Growth and Promotes Commitment in Myeloid Leukemia Cells
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