Long-term outcomes after acute myocardial infarction in patients with familial hypercholesterolemia: The French registry of Acute ST-elevation and non-ST-elevation Myocardial Infarction program

Patients with familial hypercholesterolemia (FH) are prone to develop acute myocardial infarction (AMI) at a younger age. The aim of the present study was to assess 5-year outcomes after AMI according to the presence of FH in a large multicenter cohort of patients. The French registry of Acute ST-el...

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Bibliographic Details
Published in:Journal of clinical lipidology 2020-05, Vol.14 (3), p.352-360.e6
Main Authors: Danchin, Nicolas, Farnier, Michel, Zeller, Marianne, Puymirat, Etienne, Cottin, Yves, Belle, Loïc, Lemesle, Gilles, Cayla, Guillaume, Ohlmann, Patrick, Jacquemin, Laurent, Perret, Thibault, Angoulvant, Denis, Albert, Franck, Ferrières, Jean, Schiele, François, Simon, Tabassome
Format: Article
Language:English
Subjects:
Acute myocardial infarction
Aged
Cohort Studies
Familial hypercholesterolemia
Female
France / epidemiology
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
Hyperlipoproteinemia Type II / complications
Hyperlipoproteinemia Type II / diagnosis
Hyperlipoproteinemia Type II / drug therapy
Hyperlipoproteinemia Type II / epidemiology
Life Sciences
Long-term outcome
Male
Middle Aged
Non-ST Elevated Myocardial Infarction / complications
Prognosis
Registries
Risk Factors
Santé publique et épidémiologie
ST Elevation Myocardial Infarction / complications
Surveys and Questionnaires
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Summary:Patients with familial hypercholesterolemia (FH) are prone to develop acute myocardial infarction (AMI) at a younger age. The aim of the present study was to assess 5-year outcomes after AMI according to the presence of FH in a large multicenter cohort of patients. The French registry of Acute ST-elevation and non-ST-elevation Myocardial Infarction consists of nationwide surveys recruiting patients over a 1- to 2-month period every 5 years. Patients recruited in 2005 and 2010 were followed up to 5 years. Of 5147 patients discharged alive and in whom FH status could be assessed, 2.8% had probable/definite FH, using an adapted Dutch Lipid Clinic score. They were 12 years younger, on average, than non-FH patients. Before adjustment, their 5-year survival and event-free survival did not differ from non-FH patients. After adjustment, however, both mortality (hazard ratio [HR] 1.82, 95% confidence interval [CI] 1.15–2.89; P = .011) and the combined endpoint of death, AMI, or stroke (HR 2.22, 95% CI: 1.51–3.26; P 
ISSN:1933-2874
1876-4789
DOI:10.1016/j.jacl.2020.03.008