“I do not feel my hand where I see it”: causal mapping of visuo-proprioceptive integration network in a surgical glioma patient

A recent tasked-based fMRI study unveiled a network of areas implicated in the process of visuo-proprioceptive integration of the right hand. In this study, we report a case of a patient operated on in awake conditions for a glioblastoma of the left superior parietal lobule. When stimulating a white...

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Bibliographic Details
Published in:Acta neurochirurgica 2020-08, Vol.162 (8), p.1949-1955
Main Authors: Mandonnet, Emmanuel, Margulies, Daniel, Stengel, Chloe, Dali, Mélissa, Rheault, François, Toba, Monica N., Bonnetblanc, François, Valero-Cabre, Antoni
Format: Article
Language:English
Subjects:
Brain Neoplasms - diagnostic imaging
Brain Neoplasms - physiopathology
Brain Neoplasms - surgery
Case Report - Functional Neurosurgery - Other
Case reports
Cognitive science
Evoked Potentials
Functional magnetic resonance imaging
Functional Neurosurgery – Other
Functional plasticity
Glioblastoma
Glioma
Glioma - diagnostic imaging
Glioma - physiopathology
Glioma - surgery
Hand - physiopathology
Humans
Integration
Interventional Radiology
Magnetic Resonance Imaging
Medicine
Medicine & Public Health
Minimally Invasive Surgery
Neurology
Neuroradiology
Neuroscience
Neurosurgery
Parietal Lobe - diagnostic imaging
Parietal Lobe - physiopathology
Proprioception
Substantia alba
Superior parietal lobule
Surgical Orthopedics
Visual Perception
White Matter - physiopathology
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Summary:A recent tasked-based fMRI study unveiled a network of areas implicated in the process of visuo-proprioceptive integration of the right hand. In this study, we report a case of a patient operated on in awake conditions for a glioblastoma of the left superior parietal lobule. When stimulating a white matter site in the anterior wall of the cavity, the patient spontaneously reported a discrepancy between the visual and proprioceptive perceptions of her right hand. Using several multimodal approaches (axono-cortical evoked potentials, tractography, resting-state functional connectivity), we demonstrated converging support for the hypothesis that tumor-induced plasticity redistributed the left-lateralized network of right-hand visuo-proprioceptive integration towards its right-lateralized homolog.
ISSN:0001-6268
0942-0940
DOI:10.1007/s00701-020-04399-2