Characteristics of healthy and androgenetic alopecia scalp microbiome: Effect of Lindera strychnifolia roots extract as a natural solution for its modulation

Objective The human scalp harbours a vast community of microbiotal mutualists. Androgenetic alopecia (AGA), the most common form of hair loss in males, is a multifactorial condition involving genetic predisposition and hormonal changes. The role of microflora during hair loss remains to be understoo...

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Bibliographic Details
Published in:International journal of cosmetic science 2020-12, Vol.42 (6), p.615-621
Main Authors: Filaire, E., Dreux, A., Boutot, C., Ranouille, E., Berthon, J. Y.
Format: Article
Language:English
Subjects:
Abundance
Alopecia
Alopecia - drug therapy
Alopecia - microbiology
Bacteria
Bacteria - classification
Bacteria - isolation & purification
Baldness
Composition
Cutibacterim acnes/Staphylococcus epidermidis ratio
Deoxyribonucleic acid
DNA
DNA sequencing
Eurotium
Fungi
Fungi - classification
Fungi - isolation & purification
Hair
Hair loss
hair treatment
Humans
Life Sciences
Lindera
Lindera - chemistry
Lindera strychnifolia roots extract
Malassezia
Malassezia globosa
Malassezia restricta
Male
microbiology
Microbiomes
Microbiota
Microflora
Microorganisms
Middle Aged
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Plant Roots - chemistry
Populations
Relative abundance
Ribosomal DNA
rRNA 16S
Scalp
Scalp - drug effects
scalp microbiota
Staphylococcus epidermidis
Stenotrophomonas
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Summary:Objective The human scalp harbours a vast community of microbiotal mutualists. Androgenetic alopecia (AGA), the most common form of hair loss in males, is a multifactorial condition involving genetic predisposition and hormonal changes. The role of microflora during hair loss remains to be understood. After having characterized the scalp microbiota of 12 healthy male subjects and 12 AGA male subjects (D0), the aim of this investigation was to evaluate the capacity of Lindera strychnifolia root extract (LsR) to restore a healthy bacterial and fungal scalp microflora after 83 days (D83) of treatment. Material and methods The strategy used was based on high‐throughput DNA sequencing targeting the encoding 16S ribosomal RNA for bacteria and Internal Transcribed Spacer 1 ribosomal DNA for fungi. Results Test analysis of relative abundance comparing healthy and AGA subjects showed a significant increase of Cutibacterim acnes (P 
ISSN:0142-5463
1468-2494
1467-2494
DOI:10.1111/ics.12657