Increased risk of hypercholesterolemia in a French and Lebanese population due to an interaction between rs2569190 in CD14 and gender

• Published in: Clinica chimica acta 2020-10, Vol.509, p.172-176
• Main Authors: El Shamieh, Said, Salami, Ali, Stathopoulou, Maria G., Chedid, Pia, Visvikis-Siest, Sophie
• Format: Article
• Language: English
• Subjects: Cluster of differentiation 14; Female; Genetic association analysis; Humans; Hypercholesterolemia; Hypercholesterolemia - genetics; Life Sciences; Lipopolysaccharide Receptors - genetics; Logistic Models; Male; Phenotype; Polymorphism, Single Nucleotide; Single nucleotide polymorphism
• ISSN: 0009-8981; 1873-3492
• DOI: 10.1016/j.cca.2020.06.020

•The interaction rs2569190 in CD14*gender is associated with high total cholesterol levels.•The interaction rs2569190 in CD14*gender is associated with low-density lipoprotein cholesterol levels.•Sensitivity test showed no genetic heterogeneity. Since identifying gender-specific genetic associations may have a significant impact on public health, we studied the interaction between rs2569190 in CD14 (cluster of differentiation 14) and gender in relation to the lipid traits in two independent populations. We first tested the interaction in a discovery population (SFS, n = 956), then replicated it in an independent population (LGP, n = 460), followed by a meta-analysis (n = 1,416). Finally, stratification according to gender was conducted to test the association between rs2569190 and lipid traits. Binary multiple logistic regression models were used while correcting for many confounders. Power calculations were also performed. An interaction between rs2569190 and gender, which increased the risk of total cholesterol levels in SFS, was found (OR = 2.151 and P = 0.05). This interaction was further replicated in the LGP (OR = 1.353 and P