The Scribble family in cancer: twentieth anniversary

Among the more than 160 PDZ containing proteins described in humans, the cytoplasmic scaffold Scribble stands out because of its essential role in many steps of cancer development and dissemination. Its fame has somehow blurred the importance of homologous proteins, Erbin and Lano, all belonging to...

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Published in:Oncogene 2020, Vol.39
Main Authors: Santoni, Marie-Josée, Kashyap, Rudra, Camoin, Luc, Borg, Jean-Paul
Format: Article
Language:English
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Biochemistry, Molecular Biology
Cancer
Life Sciences
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container_title Oncogene
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creator Santoni, Marie-Josée
Kashyap, Rudra
Camoin, Luc
Borg, Jean-Paul
description Among the more than 160 PDZ containing proteins described in humans, the cytoplasmic scaffold Scribble stands out because of its essential role in many steps of cancer development and dissemination. Its fame has somehow blurred the importance of homologous proteins, Erbin and Lano, all belonging to the LRR and PDZ (LAP) protein family first described twenty years ago. In this review, we will retrace the history of LAP family protein research and draw attention to their contribution in cancer by detailing the features of its members at the structural and functional levels, and highlighting their shared-but also differentimplication in the tumoral process.
doi_str_mv 10.1038/s41388-020-01478-7
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subjects Biochemistry, Molecular Biology
Cancer
Life Sciences
title The Scribble family in cancer: twentieth anniversary
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