Ruthenium complex based on [N,N,O] tridentate -2-ferrocenyl-2-thiazoline ligand for catalytic transfer hydrogenation

• Published in: Journal of organometallic chemistry 2021-01, Vol.932, p.121630, Article 121630
• Main Authors: Badillo-Gómez, J I, Sánchez-Rodríguez, E P, Toscano, R A, Gouygou, M, Ortega-Alfaro, M C, López-Cortés, J G
• Format: Article
• Language: English
• Subjects: Chemical Sciences; Coordination chemistry; Ferrocenyl ligands; Ketones; Ruthenium; Schiff base; Thiazoline; Transfer hydrogenation
• ISSN: 0022-328X; 1872-8561; 0022-328X
• DOI: 10.1016/j.jorganchem.2020.121630

•A new [N,N,O]-tridentate Schiff base ligand L1 was obtained in 83% of global yield•The structural design of L1 was inspired in a 2-Ferrocenyl-2-thiazoline as scaffold•The coordination ability of L1 towards Ru was evidenced by different techniques•The catalytic performance of [RuL1] was tested in transfer hydrogenation•[RuL1] promotes the TH in a variety of substrates giving moderated to excellent conversions A method for the synthesis of a new phosphine-free [N,N,O]-tridentate Schiff base ligand L1 using the 2-Ferrocenyl-2-thiazoline as scaffold was developed. The 1,2-disubstituted ferrocene-based ligand was assembled using as key strategy the directed ortho-metalation (DoM) in 2-ferrocenyl-2-thiazoline. L1 was successfully obtained in 83% of overall yield after two-step synthesis. The coordination ability of L1 towards Ru(II) was evidenced and the resulting complex was characterized by IR, UV-vis and EPR. Its catalytic performance was tested in transfer hydrogenation of a variety of substrates giving moderate to excellent conversions. [Display omitted]