High 18F-FDOPA PET Uptake in Primary Central Nervous System Lymphoma

ABSTRACTWe present a 42-year-old woman with primary central nervous system lymphoma (PCNSL) and strong F-FDOPA PET uptake. F-FDOPA PET has high diagnostic accuracy in gliomas and brain metastases. The L-type amino acid transporter 1, targeted by F-FDOPA and C-MET PET, is a cell-type transporter usua...

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Bibliographic Details
Published in:Clinical nuclear medicine 2021-01, Vol.46 (1), p.e59-e60
Main Authors: Salgues, Betty, Kaphan, Elsa, Molines, Elicia, Brun, Gilles, Guedj, Eric
Format: Article
Language:English
Subjects:
Adult
Biological Transport
Central Nervous System Neoplasms - diagnostic imaging
Central Nervous System Neoplasms - metabolism
Diagnosis, Differential
Dihydroxyphenylalanine - analogs & derivatives
Dihydroxyphenylalanine - metabolism
Human health and pathology
Humans
Life Sciences
Lymphoma, Non-Hodgkin - diagnostic imaging
Lymphoma, Non-Hodgkin - metabolism
Male
Positron-Emission Tomography
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Summary:ABSTRACTWe present a 42-year-old woman with primary central nervous system lymphoma (PCNSL) and strong F-FDOPA PET uptake. F-FDOPA PET has high diagnostic accuracy in gliomas and brain metastases. The L-type amino acid transporter 1, targeted by F-FDOPA and C-MET PET, is a cell-type transporter usually upregulated in malignant tumors, including PCNSL. In this line, strong uptake was already shown with C-MET in PCNSL. We report the same findings with F-FDOPA. Consequently, PCNSL is a possible differential neoplastic diagnosis of F-FDOPA uptake among neoplastic lesions.
ISSN:0363-9762
1536-0229
DOI:10.1097/RLU.0000000000003303