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Dendritic metal complexes for bioimaging. Recent advances
[Display omitted] •Dendrimer complexes have many biological properties.•Dendrimer complexes can be specifically engineered for imaging.•Dendrimer complexes can be used for optical imaging.•Dendrimer complexes of gadolinium are useful contrast agents for magnetic resonance imaging in vivo.•Dendrimer...
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Published in: | Coordination chemistry reviews 2021-03, Vol.430, p.213739, Article 213739 |
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Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | [Display omitted]
•Dendrimer complexes have many biological properties.•Dendrimer complexes can be specifically engineered for imaging.•Dendrimer complexes can be used for optical imaging.•Dendrimer complexes of gadolinium are useful contrast agents for magnetic resonance imaging in vivo.•Dendrimer complexes of 99mTc or 111In are useful agents for single photon emission computed tomography in vivo.
Dendrimers are hyperbranched macromolecules, having a large number of terminal functions, easily accessible and modifiable to afford the desired properties. Metal complexes of dendrimers are frequently used as catalysts in diverse reactions, but they can be used also as innovative biological tools. This review focusses on the recent advances (last 10 years) of dendritic metal complexes used for bioimaging, essentially in vivo. Three main domains will be covered. The first one concerns luminescent complexes for optical imaging (OI). The second one is the largest one; it concerns magnetic resonance imaging (MRI) contrast agents, mostly based on gadolinium complexes. The third and last domain concerns radioactive dendrimer complexes for single photon emission computed tomography (SPECT), and also for positron emission tomography (PET). Two main radionuclides are used in this context, technetium (99mTc) and indium (111In). Two types of ligands are generally used for all these complexes in the two last domains, diethylenetriaminepentaacetic acid (DTPA), and a cyclic analogue, 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA), and some of their derivatives. These complexes have been used in many cases for in vivo imaging of cancerous tumors in mice or rats. |
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ISSN: | 0010-8545 1873-3840 0010-8545 |
DOI: | 10.1016/j.ccr.2020.213739 |