Effect of orthopedic implants on canine long bone compression stiffness: a combined experimental and computational approach

• Published in: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine Journal of engineering in medicine, 2020-03, Vol.234 (3), p.255-264
• Main Authors: Laurent, Cédric P, Böhme, Béatrice, Verwaerde, Jolanthe, Papeleux, Luc, Ponthot, Jean-Philippe, Balligand, Marc
• Format: Article
• Language: English
• Subjects: Animal biology; Animals; Bioengineering; Biomaterials; Biomechanical Phenomena; Biomechanics; Biomedical materials; Biotechnology; Bone implants; Bones; Cell Behavior; Cellular Biology; Compression; Compression tests; Compressive Strength; Computer applications; Computer simulation; Dogs; Engineering Sciences; Finite Element Analysis; Finite element method; Humerus - physiology; Imaging; Life Sciences; Locking; Long bone; Material properties; Materials; Materials and structures in mechanics; Mechanical properties; Mechanical Tests; Mechanics; Mechanics of materials; Orthopaedic implants; Orthopedics; Osteosynthesis; Physics; Prostheses and Implants; Solid mechanics; Stiffness; Structural mechanics; Subcellular Processes; Surgical implants; Transplants & implants; Veterinary medicine and animal Health; Veterinary surgeons; Vibrations
• ISSN: 0954-4119; 2041-3033
• DOI: 10.1177/0954411919882603

Osteosynthesis for canine long bones is a complex process requiring knowledge of biology, surgical techniques and (bio)mechanical principles. Subject-specific finite element analysis constitutes a promising tool to evaluate the effect of surgical intervention on the global properties of a bone–implant construct, but suffers from a lack of validation. In this study, the biomechanical behavior of 10 canine humeri was compared before and after creation of a 10 mm bone defect stabilized with an eight-hole locking compression plate (Synthes®) and two locking screws on each fragment. The response under compression of both intact and plated samples was measured experimentally and reproduced with a finite element model. The experimental stiffness ratio between plated and intact bone was equal to 0.39 ± 0.06. A subject-specific finite element analysis including density-dependent elasto-plastic material properties for canine bone and automatic generation of orthopedic implants was then conducted to recover these experimental results. The stiffness of intact and plated samples could be predicted, with no significant differences with experimental data. The simulated stiffness ratio between plated and intact canine bone was equal to 0.43 ± 0.03. This study constitutes a first step toward the building of a virtual database of pre-computed cases, aiming at helping the veterinary surgeons to make decisions regarding the most suited orthopedic solution for a given dog and a given fracture.