Mesenchymal stem cell‐derived small extracellular vesicles as cell‐free therapy: Perspectives in periodontal regeneration

Mesenchymal stem cells (MSC) are involved in the regeneration of the different missing or compromised periodontal tissues. MSC‐derived small extracellular vesicles (sEV) have recently been explored as a favorable substitution for stem cell therapy, as they are capable of producing therapeutic effect...

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Bibliographic Details
Published in:Journal of periodontal research 2021-06, Vol.56 (3), p.433-442
Main Authors: Novello, Solen, Pellen‐Mussi, Pascal, Jeanne, Sylvie
Format: Article
Language:English
Subjects:
Animals
Cell therapy
Cell- and Tissue-Based Therapy
cell‐free therapy
Chemical Sciences
Dentistry
exosomes
Extracellular Vesicles
Mesenchymal Stem Cells
periodontal regeneration
Periodontium
Regeneration
Reviews
small extracellular vesicles
Stem cell transplantation
Stem cells
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Summary:Mesenchymal stem cells (MSC) are involved in the regeneration of the different missing or compromised periodontal tissues. MSC‐derived small extracellular vesicles (sEV) have recently been explored as a favorable substitution for stem cell therapy, as they are capable of producing therapeutic effects comparable to those of their parent cells, with advantages over cell therapy. The aim of this review is to evaluate the use of mesenchymal stem cells (MSC)‐derived sEV as cell‐free therapy in periodontal regeneration. A review of the scientific literature on sEV and their use in periodontal regeneration was performed. The main characteristics of sEV are described, and their mechanisms of action and potential biological effects in periodontal regeneration are studied. A summary of existing preclinical studies conducted in animals is performed. The results indicate that sEV derived from MSC are emerging as a promising new therapeutic tool in the field of periodontal regeneration and may become an ideal therapeutic option. In this review, we have summarized recent advances in this regard in order to better understand this newly emerging treatment. First results in vivo are promising and show a favorable potential for cell‐free therapy in periodontal regeneration.
ISSN:0022-3484
1600-0765
DOI:10.1111/jre.12866