Cardiovascular Outcomes Reported in Hemodialysis Trials

Patients on long-term hemodialysis are at very high risk for cardiovascular disease but are usually excluded from clinical trials conducted in the general population or in at-risk populations. There are no universally agreed cardiovascular outcomes for trials conducted specifically in the hemodialys...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2018-06, Vol.71 (24), p.2802-2810
Main Authors: O’Lone, Emma, Viecelli, Andrea K., Craig, Jonathan C., Tong, Allison, Sautenet, Benedicte, Roy, David, Herrington, William G., Herzog, Charles A., Jafar, Tazeen, Jardine, Meg, Krane, Vera, Levin, Adeera, Malyszko, Jolanta, Rocco, Michael V., Strippoli, Giovanni, Tonelli, Marcello, Wang, Angela Yee Moon, Wanner, Christoph, Zannad, Faiez, Winkelmayer, Wolfgang C., Webster, Angela C., Wheeler, David C.
Format: Article
Language:English
Subjects:
Cardiology
cardiovascular
Cardiovascular disease
Cardiovascular diseases
Clinical decision making
Clinical trials
composites
Decision making
Dialysis
Economic impact
Health care
Health risks
Hemodialysis
Impact analysis
Initiatives
Intervention
Kidney diseases
Life Sciences
Medical personnel
Medical research
Mortality
Nephrology
outcomes
Patients
Rheumatology
Risk
Systematic review
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Summary:Patients on long-term hemodialysis are at very high risk for cardiovascular disease but are usually excluded from clinical trials conducted in the general population or in at-risk populations. There are no universally agreed cardiovascular outcomes for trials conducted specifically in the hemodialysis population. In this review, we highlight that trials reporting cardiovascular outcomes in hemodialysis patients are usually of short duration (median 3 to 6 months) and are small (59% of trials have 
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2018.04.012